Evidence map›Paper›PMID 36018756›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction.

Alejandro R Chade, Alfonso Eirin

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Review
  3. When in doubt, pig it out: a versatile translational platform to study CKD, HFpEF, and CKM syndrome.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. A minimally invasive swine model of chronic kidney disease-associated heart failure.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alejandro R ChadeDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-3672-3409
Alfonso EirinDivision of Nephrology and Hypertension, Department of Physiology and Biophysics, Medicine, and Radiology, Mayo Clinic, Jackson, Mississippi.
Jackson Memorial Hospital · US

Funding

Role of mitochondrial microRNAs (mitomiRs) in endogenous renal repairR01DK129240 · NIDDK · MAYO CLINIC ROCHESTER · 2024 to 2025
$897k
Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · MAYO CLINIC ROCHESTER · 2025 to 2025
$692k
NHLBI NIH HHS R01 HL095638NHLBI NIH HHS R01 HL158691NIDDK NIH HHS R01 DK129240NIDDK NIH HHS R56 DK129240NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is an independent risk factor for the development of heart failure, but the underlying mechanisms remain unknown. Using a novel translational swine model of CKD and cardiac dysfunction, we hypothesize that CKD alters the cardiac miRNA and transcriptomic profile that associate with cardiac remodeling and metabolic processes implicated in the development of left ventricular diastolic dysfunction (CKD-LVDD). CKD-LVDD and normal control pigs (

Indexed as

MicroRNAsRenal Insufficiency, ChronicVentricular Dysfunction, LeftAdenosine TriphosphateAnimalsDiastoleFatty AcidsLipidsRNA, MessengerSwineTranscriptomeVentricular RemodelingAdenosine TriphosphateFatty AcidsLipidsMicroRNAsRNA, Messengerchronic kidney diseaseheart failuremicro-RNAspathophysiologytranscriptomic

Identifiers

PMID36018756
PMCPMC9512116
OpenAlexW4293162121

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.