ReviewWorld journal of microbiology & biotechnology2022
Genetic and metabolic engineering for poly-γ-glutamic acid production: current progress, challenges, and prospects.
Review in World journal of microbiology & biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Polyglutamic Acid as an Antiviral Agent: Mechanistic and Structural Insights.Pharmaceutics · 2025Review
- Development of the autonomous lab system to support biotechnology research.Scientific reports · 2025Article
- Screening and Identification of Natural Compounds as Potential Inhibitors of Glutamate Racemase, an Emerging Drug Target of Food PathogenInfectious disorders drug targets · 2025Article
- Investigation of γ-polyglutamic acid production via asynchronous saccharification and fermentation of raw corn starch.World journal of microbiology & biotechnology · 2024Article
- Modular metabolic engineering of Bacillus amyloliquefaciens for high-level production of green biosurfactant iturin A.Applied microbiology and biotechnology · 2024Article
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Accompanied with the developments of gene editing and synthetic biology toolkits, various metabolic engineering strategies have been established for strain improvement to enhance the target metabolite production. Poly-γ-glutamic acid (γ-PGA) is a natural biopolymer that mainly produced by Bacillus, and low-level yield hinders its application. To address this problem, numerous approaches have been conducted to increase γ-PGA yield. In this review, we focus on the genetic and metabolic engineering of microorganism for γ-PGA production, including strengthening raw materials utilization and precursor supply, enhancing γ-PGA synthetase gene cluster, transcription regulation engineering, cofactor regeneration, energy engineering and blocking the synthetic pathways of by-products. Meanwhile, to attain the γ-PGA with different configurations (D/L) and molecular weights, the expression of γ-PGA synthetase, glutamate racemase and γ-PGA hydrolase were respectively manipulated. In addition, except for Bacillus, metabolic engineering of other hosts for high-level production of γ-PGA was also reviewed in this article. Finally, the prospect of metabolic engineering of γ-PGA production strain was discussed regarding the recent progress, challenge, and trends in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.