Evidence map›Paper›PMID 36032295›Full record

ArticleFrontiers in veterinary science2022

Analysis of gene expression in monocytes of immunized pigs after infection with homologous or heterologous African swine fever virus.

Natalia Kholod, Andrey Koltsov, Galina Koltsova

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia KholodLaboratory of Viral Genomics, Federal Research Center for Virology and Microbiology, Pokrov, Russia.
Andrey KoltsovLaboratory of Viral Genomics, Federal Research Center for Virology and Microbiology, Pokrov, Russia.
Galina KoltsovaLaboratory of Viral Genomics, Federal Research Center for Virology and Microbiology, Pokrov, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever is a deadly disease of pigs caused by the large DNA virus (ASFV). Despite intensive research, little is known about the molecular mechanisms of ASFV pathogenesis. Transcriptome analysis of host and viral genes in infected macrophages revealed changes in expression of genes involved in various biological processes, including immune response, inflammatory response and apoptosis. To understand the mechanisms of virus pathogenesis, we used transcriptome analysis to identify the differences in gene expression between peripheral blood monocytes (PBMCs) isolated from pigs immunized with attenuated Congo ASFV strain (KK262), and then infected

Indexed as

African swine fever virusheterologous ASFV strainhomologous ASFV strainseroimmunotypetranscriptome

Identifiers

PMID36032295
PMCPMC9411669

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.