Evidence map›Paper›PMID 36033397›Full record

ArticleJournal of immunology research2022

BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.

Amanda Contreras, Darin L Wiesner, Brock Kingstad-Bakke, Woojong Lee, John P Svaren, Bruce S Klein, M Suresh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Notch2 Directs aTreg Cell Fate Toward Immunoregulation or Inflammatory Pyroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amanda ContrerasDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Darin L WiesnerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Brock Kingstad-BakkeDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Woojong LeeDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, 53706 WI, USA.
John P SvarenDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Bruce S KleinDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, 53706 WI, USA.
M SureshDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, 53706 WI, USA.ORCID https://orcid.org/0000-0003-1794-3358
University of Wisconsin–Madison · US

Funding

PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Mucosal Adjuvant to Induce Multipronged T Cell Immunity to TuberculosisR21AI149793 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SURESH, MARULASIDDAPPA · 2020 to 2021
$427k
NIAID NIH HHS R01 AI040996NIAID NIH HHS R21 AI149793NIAID NIH HHS T32 AI055397NIAID NIH HHS U01 AI124299
6 · The paper itself

Abstract

FoxP3+ regulatory T cells (Tregs) are essential for self-tolerance and moderating tissue-damaging inflammation. Tregs that develop and mature in the thymus are classified as central Tregs or effector Tregs based on whether Tregs predominately inhabit secondary lymphoid organs (central Tregs) or tissues (effector Tregs). By generating mice that are conditionally deficient for Bach2 in peripheral Tregs, we have examined the role of Bach2 in regulating Treg homeostasis and effector functions. Unlike global and T cell-specific Bach2-deficient mice, Treg-specific Bach2 ablation did not result in unprovoked T

Indexed as

HypersensitivityT-Lymphocytes, RegulatoryAdipose TissueAllergensAnimalsBasic-Leucine Zipper Transcription FactorsForkhead Transcription FactorsFungal ProteinsInflammationMiceMice, Inbred C57BLAllergensBach2 protein, mouseBasic-Leucine Zipper Transcription FactorsForkhead Transcription FactorsFungal Proteins

Identifiers

PMID36033397
PMCPMC9410868
OpenAlexW4290034612

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.