Evidence map›Paper›PMID 36033512›Full record

ArticleFrontiers in oncology2022

Gene expression analysis reveals a 5-gene signature for progression-free survival in prostate cancer.

Zhuofan Mou, Jack Spencer, Bridget Knight, Joseph John, Paul McCullagh, John S McGrath, Lorna W Harries

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhuofan MouInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Devon, United Kingdom.
Jack SpencerTranslational Research Exchange at Exeter, Living Systems Institute, University of Exeter, Exeter, United Kingdom.
Bridget KnightNational Institute for Health and Care Research (NIHR) Exeter Clinical Research Facility, Royal Devon and Exeter National Health Service (NHS) Foundation Trust, Royal Devon and Exeter Hospital, Exeter, United Kingdom.
Joseph JohnInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Devon, United Kingdom.
Paul McCullaghDepartment of Pathology, Royal Devon and Exeter National Health Service (NHS) Foundation Trust, Exeter, United Kingdom.
John S McGrathInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Devon, United Kingdom.
Lorna W HarriesInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Devon, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most common male cancer worldwide, but effective biomarkers for the presence or progression risk of disease are currently elusive. In a series of nine matched histologically confirmed PCa and benign samples, we carried out an integrated transcriptome-wide gene expression analysis, including differential gene expression analysis and weighted gene co-expression network analysis (WGCNA), which identified a set of potential gene markers highly associated with tumour status (malignant

Indexed as

gene signatureprediction modelprognosisprostate cancertranscriptomics

Identifiers

PMID36033512
PMCPMC9413154

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.