ArticleFrontiers in nutrition2022
Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human milk composition in women with gestational diabetes mellitus: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk.Biochemical Society transactions · 2026Review
- Lactose quantification in human breast milk by gas chromatography - mass spectrometry.MethodsX · 2026Article
- Ethnicity and antenatal maternal anxiety: associations with the human milk lipidome in a multi-ethnic Asian cohort.Frontiers in nutrition · 2026Article
- Nursing Care in Obstetrics and Breastfeeding Practices in Gestational Diabetic Mothers in China: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Antioxidant Capacity of Colostrum of Mothers with Gestational Diabetes Mellitus-A Cross-Sectional Study.Nutrients · 2025Article
- Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding.Journal of diabetes investigation · 2025Article
- Gestational Diabetes, the Human Milk Metabolome, and Infant Growth and Adiposity.JAMA network open · 2024Article
- Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus.World journal of diabetes · 2024Article
- The unrevealed links: periodontal health, human milk composition, and infant gut microbiome dynamics.Primary health care research & development · 2024Review
- Gut Microbiota Associated with Gestational Health Conditions in a Sample of Mexican Women.Nutrients · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) commonly leads to adverse pregnancy outcomes and long-term metabolic complications in offspring. Breastfeeding has been shown to rewrite the fetal "metabolic programming" resulting from maternal diabetes and finally lead to a lower risk of future metabolic disease. Lipids in breast milk act like hormones to promote infant growth and development, but there is minimal information invested thus far in constitution changes of lipids in breast milk, especially in the context of GDM. In the present study, we performed a lipidomics analysis to compare the lipid composition in breast milk collected from women with or without GDM. We further revealed the correlations of dysregulated lipids in breast milk with maternal glucose and infant physical development. A total of 833 lipid species from 15 classes were identified, 60 of which were found to be significantly altered in response to the high glucose, suggesting a remarkable lipid profiling change in breast milk induced by GDM. Our results showed significant associations between dysregulated lipids (e.g., neutral lipids, phospholipids, sphingolipids) and maternal glucose. Furthermore, correction analysis demonstrated that GDM related lipids were also associated with indicators of infant physical development, including body weight, length, and head circumference. These findings may help to understand the protective effects of breastfeeding especially during GDM pregnancy.
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