ArticleFrontiers in nutrition2022
Efficient screening of pancreatic lipase inhibitors from cod meat hydrolysate through ligand fishing strategy.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Purification, Identification, andMarine drugs · 2025Article
- Synthesis and Characterization of Short α and β-Mixed Peptides with Excellent Anti-Lipase Activities.Molecules (Basel, Switzerland) · 2024Article
- Efficient recovery of functional biomolecules from shrimp (Current research in food science · 2024Article
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Authors and funding
5 authors.
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Abstract
Obesity has become an increasingly serious public health problem. Pancreatic lipase (PL) is identified as a ideal target for the prevention and treatment of obesity. Orlistat, the only approved PL inhibitor (PLI), is a powerful weight loss drug but has many side effects. Therefore, there is an urgent need to discover powerful PLIs with high safety. Protein hydrolysate has been demonstrated to be a treasure trove of PLIs, but recognizing responsible functional peptides from them is like looking for a needle in a haystack. In this work, we synthesized and optimized a PL ligand fishing model (PLLFM) using magnetic nanoparticles (MNPs), then PLLFM was used to quickly fish out potential PLIs from the Cod meat hydrolysate (CMH). Finally, two new PLIs, GSPPPSG and KLEGDLK were identified with IC
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