Evidence map›Paper›PMID 36037472›Full record

ArticleAnnals of internal medicine2022

Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study.

Maki Inoue-Choi, Yesenia Ramirez, Marilyn C Cornelis, Amy Berrington de González, Neal D Freedman, Erikka Loftfield

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In one paragraph

Article in Annals of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Maki Inoue-ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.I.C., Y.R., A.B.G., N.D.F., E.L.).ORCID 0000-0002-0070-7829
Yesenia RamirezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.I.C., Y.R., A.B.G., N.D.F., E.L.).
Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois (M.C.C.).ORCID 0000-0002-0699-1664
Amy Berrington de GonzálezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.I.C., Y.R., A.B.G., N.D.F., E.L.).ORCID 0000-0002-7332-8387
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.I.C., Y.R., A.B.G., N.D.F., E.L.).
Erikka LoftfieldDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.I.C., Y.R., A.B.G., N.D.F., E.L.).ORCID 0000-0002-3573-8748

Funding

Etiologic Studies of Diet and CancerZIACP010127 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$3.5M
Intramural NIH HHS Z99 CA999999Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Wellcome Trust
6 · The paper itself

Abstract

backgroundTea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.

objectiveTo evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.

designProspective cohort study.

settingThe UK Biobank.

participants498 043 men and women aged 40 to 69 years who completed the baseline touchscreen questionnaire from 2006 to 2010. MEASUREMENTS: Self-reported tea intake and mortality from all causes and leading causes of death, including cancer, all cardiovascular disease (CVD), ischemic heart disease, stroke, and respiratory disease.

resultsDuring a median follow-up of 11.2 years, higher tea intake was modestly associated with lower all-cause mortality risk among those who drank 2 or more cups per day. Relative to no tea drinking, the hazard ratios (95% CIs) for participants drinking 1 or fewer, 2 to 3, 4 to 5, 6 to 7, 8 to 9, and 10 or more cups per day were 0.95 (95% CI, 0.91 to 1.00), 0.87 (CI, 0.84 to 0.91), 0.88 (CI, 0.84 to 0.91), 0.88 (CI, 0.84 to 0.92), 0.91 (CI, 0.86 to 0.97), and 0.89 (CI, 0.84 to 0.95), respectively. Inverse associations were seen for mortality from all CVD, ischemic heart disease, and stroke. Findings were similar regardless of whether participants also drank coffee or not or of genetic score for caffeine metabolism. LIMITATION: Potentially important aspects of tea intake (for example, portion size and tea strength) were not assessed.

conclusionHigher tea intake was associated with lower mortality risk among those drinking 2 or more cups per day, regardless of genetic variation in caffeine metabolism. These findings suggest that tea, even at higher levels of intake, can be part of a healthy diet. PRIMARY FUNDING SOURCE: National Cancer Institute Intramural Research Program.

Indexed as

Cardiovascular DiseasesMyocardial IschemiaStrokeBiological Specimen BanksCaffeineCause of DeathCoffeeFemaleFollow-Up StudiesHumansMaleProspective StudiesRisk FactorsTeaUnited KingdomCaffeineCoffeeTea

Identifiers

PMID36037472
PMCPMC10623338

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.