Evidence map›Paper›PMID 36038266›Full record

ArticleBiological chemistry2022

Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na

Guido Gessner, Mahdi Jamili, Pascal Tomczyk, Dirk Menche, Roland Schönherr, Toshinori Hoshi, Stefan H Heinemann

Open access · greenAbstract read
In one paragraph

Article in Biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Guido GessnerDepartment of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.
Mahdi JamiliDepartment of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.
Pascal TomczykKekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, D-53121 Bonn, Germany.
Dirk MencheKekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, D-53121 Bonn, Germany.
Roland SchönherrDepartment of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.
Toshinori HoshiDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104-6085, USA.
Stefan H HeinemannDepartment of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Straße 2, D-07745 Jena, Germany.ORCID 0000-0002-4144-0251
Jena University Hospital · DEUniversity of Bonn · DEUniversity of Pennsylvania · US

Funding

Mechanism of blood pressure lowering by fatty acid nutraceuticalsR01GM121375 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI HOSHI, TOSHINORI · 2017 to 2020
$2.3M
NIGMS NIH HHS R01 GM121375
6 · The paper itself

Abstract

Heme (Fe

Indexed as

Spider VenomsAnimalsBinding SitesHeminHumansPeptidesProtein BindingRatsHeminPeptidesSpider VenomshemeNaV1.5SCN5Asodium channelvoltage sensor

Identifiers

PMID36038266
PMCPMC9661527
OpenAlexW4293528491

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.