Evidence map›Paper›PMID 36040168›Full record

ArticleMicrobiology spectrum2022

Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors.

Jim Zoladek, Julien Burlaud-Gaillard, Maxime Chazal, Sophie Desgraupes, Patricia Jeannin, Antoine Gessain, Nathalie Pardigon, Mathieu Hubert, Philippe Roingeard, Nolwenn Jouvenet and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jim ZoladekUnité Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.ORCID 0000-0003-0715-251X
Julien Burlaud-GaillardInserm U1259 MAVIVH, Université de Tours and CHRU de Tours, Tours, France.
Maxime ChazalUnité Signalisation Antivirale, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.
Sophie DesgraupesUnité Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.
Patricia JeanninUnité Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.
Antoine GessainUnité Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.
Nathalie PardigonGroupe Arbovirus, Unité Environnement et Risques Infectieux, Institut Pasteurgrid.428999.7, Université Paris Cité, Paris, France.
Mathieu HubertUnité Virus et Immunité, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.
Philippe RoingeardInserm U1259 MAVIVH, Université de Tours and CHRU de Tours, Tours, France.
Nolwenn JouvenetUnité Signalisation Antivirale, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.ORCID 0000-0001-6103-6048
Philippe V AfonsoUnité Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS UMR 3569, Paris, France.ORCID 0000-0002-4828-3797
Centre National de la Recherche Scientifique · FRUniversité de Tours · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged in the Pacific islands in 2007 and spread to the Americas in 2015. The infection remains asymptomatic in most cases but can be associated with severe neurological disorders. Despite massive efforts, no specific drug or vaccine against ZIKV infection is available to date. Claudins are tight-junction proteins that favor the entry of several flaviviruses, including ZIKV. In this study, we identified two peptides derived from the N-terminal sequences of claudin-7 and claudin-1, named CL7.1 and CL1.1, respectively, that inhibited ZIKV infection in a panel of human cell lines. Using cell-to-cell fusion assays, we demonstrated that these peptides blocked the ZIKV E-mediated membrane fusion. A comparison of the antiviral efficacy of CL1.1 and CL7.1 pointed to the importance of the peptide amphipathicity. Electron microscopic analysis revealed that CL1.1 altered the ultrastructure of the viral particles likely by binding the virus lipid envelope. However, amphipathicity could not fully explain the antiviral activity of CL1.1

Indexed as

ClaudinsMembrane FusionZika VirusZika Virus InfectionAntiviral AgentsClaudin-1HumansLipidsPeptidesAntiviral AgentsClaudin-1ClaudinsLipidsPeptidesantimicrobial peptidesclaudinflavivirusZika

Identifiers

PMID36040168
PMCPMC9603178
OpenAlexW4293567366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.