ArticleJournal of diabetes2022
Association between metabolic phenotype and urinary albumin-creatinine ratio in Chinese community adults: A cross-sectional study.
Article in Journal of diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Urinary Albumin-to-Creatinine Ratio, Cardiovascular Health, and All-Cause Mortality in Hypertension: A Nationwide Cohort Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Cardiometabolic risk phenotypes and chronic kidney disease incidence in older adults: a nationwide longitudinal cohort study.BMC public health · 2025Article
- Serum metabolic profiling in diabetic kidney disease patients using ultra-high performance liquid chromatography-tandem mass spectrometry.Diabetology & metabolic syndrome · 2025Article
- A metabolic epidemic? Prevalence and sex-based disparities of metabolic alterations in the peruvian population using multiple diagnostic criteria.Journal of diabetes and metabolic disorders · 2025Article
- Prevalence and factors associated with unhealthy metabolic status according to body mass index: analysis of a national nutritional survey.Diabetology & metabolic syndrome · 2024Article
- Association between major dietary patterns and obesity phenotypes in southwest China: baseline survey results from Hechuan.Frontiers in nutrition · 2024Article
- Association of Serum Tsukushi Levels with Urinary Albumin-Creatinine Ratio in Type 2 Diabetes Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association between metabolic phenotype and urinary albumin-creatinine ratio in Chinese community adults: A cross-sectional study.Journal of diabetes · 2022Article
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Authors and funding
16 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary albumin-creatinine ratio (UACR) is a sensitive marker of kidney injury. This study analyzed the prevalence of different metabolic phenotypes and investigated their relationship with UACR in Chinese community adults.
methodsThis study involved 33 303 participants over 40 years old from seven centers across China. They were stratified into six groups according to their body mass index (BMI) and metabolic status: metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and metabolically unhealthy obesity (MUO). Increased albuminuria was defined as a UACR ≥30 mg/g.
resultsThe percentages of MHNW, MHOW, MHO, MUNW, MUOW, and MUO were 27.6%, 15.9%, 4.1%, 19.8%, 22.5%, and 9.6%, respectively. Multiple logistic regression analysis showed that the MHO group (odds ratio [OR] 1.205; 95% CI, 1.081-1.343), MUNW group (OR 1.232; 95% CI, 1.021-1.486), MUOW group (OR 1.447; 95% CI, 1.303-1.607), and MUO group (OR 1.912; 95% CI, 1.680-2.176) were at higher risk of increased albuminuria compared to the MHNW group. Subgroup analysis indicated that the risk of increased albuminuria was further elevated among regular smokers in men aged 40 to 55 years old with abdominal obesity.
conclusionsAmong Chinese community adults, increased albuminuria was associated with increased BMI whether metabolism was normal or not, and those with abnormal metabolism were at greater risk of increased albuminuria than those with normal metabolism. These findings suggest that overweight or obesity or metabolic abnormalities are risk factors for chronic kidney disease.
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