Evidence map›Paper›PMID 36040213›Full record

ArticleThe Journal of physiology2022

Regulation of corticotropin-releasing hormone neuronal network activity by noradrenergic stress signals.

Julia M Gouws, Aidan Sherrington, Shaojie Zheng, Joon S Kim, Karl J Iremonger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Direct Modulation of CRH Nerve Terminal Function by Noradrenaline and Corticosterone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Julia M GouwsCentre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand.
Aidan SherringtonCentre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand.
Shaojie ZhengCentre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand.ORCID 0000-0002-5569-931X
Joon S KimCentre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand.
Karl J IremongerCentre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand.ORCID 0000-0002-8976-2401
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noradrenaline is a neurotransmitter released in response to homeostatic challenge and activates the hypothalamic-pituitary-adrenal axis via stimulation of corticotropin-releasing hormone (CRH) neurons. Here we investigated the mechanism through which noradrenaline regulates activity within the CRH neuronal network. Using a combination of in vitro GCaMP6f Ca

Indexed as

Corticotropin-Releasing HormoneHypothalamo-Hypophyseal Systemalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCorticosteroneGlutamatesMiceNeuronsNorepinephrinePituitary-Adrenal SystemReceptors, Adrenergic, alpha-1Receptors, N-Methyl-D-AspartateSodiumalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCorticosteroneCorticotropin-Releasing HormoneGlutamatesNorepinephrineReceptors, Adrenergic, alpha-1Receptors, N-Methyl-D-AspartateSodiumCRHhypothalamusnoradrenalinestress

Identifiers

PMID36040213
PMCPMC9825848
OpenAlexW4293567401

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.