Evidence map›Paper›PMID 36041433›Full record

ArticleNeuron2022

A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking.

Ananya Chowdhury, Alessandro Luchetti, Giselle Fernandes, Daniel Almeida Filho, George Kastellakis, Alexandra Tzilivaki, Erica M Ramirez, Mary Y Tran, Panayiota Poirazi, Alcino J Silva

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 109 citations in OpenAlex.

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  14. Dopamine System Dysfunction in Alzheimer's Disease.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ananya ChowdhuryDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address: ananyachowdhury@mednet.ucla.edu.
Alessandro LuchettiDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
Giselle FernandesDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
Daniel Almeida FilhoDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
George KastellakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas (FORTH), Vassilica Vouton, PO Box 1527, GR 711 10 Heraklion, Crete, Greece.
Alexandra TzilivakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas (FORTH), Vassilica Vouton, PO Box 1527, GR 711 10 Heraklion, Crete, Greece; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany; Einstein Center for Neurosciences Berlin, Charitéplatz 1, 10117 Berlin, Germany; Neurocure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany.
Erica M RamirezDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
Mary Y TranDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas (FORTH), Vassilica Vouton, PO Box 1527, GR 711 10 Heraklion, Crete, Greece.
Alcino J SilvaDepartments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address: silvaa@mednet.ucla.edu.
Foundation for Research and Technology Hellas · GREinstein Center for Neurosciences Berlin · DE

Funding

Gene Targeting Approaches to Learning and Memory StudiesR37AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2007 to 2016
$5.4M
Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingRF1AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2022
$4.9M
CCR5 Activation and Cognitive Dysfunction Caused by HIV-ProteinsR01NS106969 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$3.7M
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4M
Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingR01AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani · 1995 to 2026
$3.3M
Building and sharing next generation open-source, wireless, multichannel miniaturized microsopes for imaging activity in freely behaving miceU01NS094286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, KHAKH, BALJIT · 2015 to 2017
$2.7M
Molecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric DisordersR01MH113071 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$2.3M
NIA NIH HHS R01 AG013622NIA NIH HHS R37 AG013622NIA NIH HHS RF1 AG013622NIMH NIH HHS R01 MH113071NIMH NIH HHS R01 MH124867NINDS NIH HHS R01 NS106969NINDS NIH HHS U01 NS094286
6 · The paper itself

Abstract

Individual memories are often linked so that the recall of one triggers the recall of another. For example, contextual memories acquired close in time can be linked, and this is known to depend on a temporary increase in excitability that drives the overlap between dorsal CA1 (dCA1) hippocampal ensembles that encode the linked memories. Here, we show that locus coeruleus (LC) cells projecting to dCA1 have a key permissive role in contextual memory linking, without affecting contextual memory formation, and that this effect is mediated by dopamine. Additionally, we found that LC-to-dCA1-projecting neurons modulate the excitability of dCA1 neurons and the extent of overlap between dCA1 memory ensembles as well as the stability of coactivity patterns within these ensembles. This discovery of a neuromodulatory system that specifically affects memory linking without affecting memory formation reveals a fundamental separation between the brain mechanisms modulating these two distinct processes.

Indexed as

DopamineLocus CoeruleusHippocampusMemoryNeuronsDopaminecontextual memorydopaminedorsal hippocampusensembleslocus coeruleusmedian raphememory linkingneuromodulationneuronal excitability

Identifiers

PMID36041433
PMCPMC10508214
OpenAlexW4293462133

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.