Evidence map›Paper›PMID 36042296›Full record

ReviewNature reviews. Microbiology2023

Staphylococcus epidermidis and its dual lifestyle in skin health and infection.

Morgan M Severn, Alexander R Horswill

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 1 pooled it
55.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 1 synthesis or guideline pooled it, 291 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Emerging microbes & infections · 2026
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  13. Delayed mycotic aneurysm of the superficial temporal artery.Journal of vascular surgery cases and innovative techniques · 2026
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  15. Ultrafast-light driven plasmonic inactivation ofJournal of materials chemistry. B · 2026
    Article
  16. Search for Potentially VirulentInternational journal of molecular sciences · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Pain and infection are the primary reasons for elective retrieval of bone-anchored implants.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article

145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Morgan M SevernDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-5101-7038
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. Alexander.horswill@cuanschutz.edu.ORCID 0000-0002-5568-0096
University of Colorado Denver · USVA Eastern Colorado Health Care System · US

Funding

Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Mechanisms of staphylococcal skin colonizationR01AI162964 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL D FEY, ANDREW B HERR · 2022 to 2026
$2.4M
Mechanisms of staphylococcal skin colonizationR56AI162964 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FEY, PAUL D, HERR, ANDREW B · 2021 to 2021
$651k
Mechanisms of skin commensal colonization resistance against opportunistic StaphylococciF31AI157052 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BROWN, MORGAN · 2021 to 2021
$27k
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711NIAID NIH HHS F31 AI157052NIAID NIH HHS R01 AI153185NIAID NIH HHS R01 AI162964NIAID NIH HHS R56 AI162964
6 · The paper itself

Abstract

The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes the cutaneous immune response, maintains skin homeostasis and prevents opportunistic pathogens from causing disease via colonization resistance. However, it is now appreciated that S. epidermidis and its interactions with the host exist on a spectrum of potential pathogenicity derived from its high strain-level heterogeneity. S. epidermidis is the most common cause of implant-associated infections and is a canonical opportunistic biofilm former. Additional emerging evidence suggests that some strains of S. epidermidis may contribute to the pathogenesis of common skin diseases. Here, we highlight new developments in our understanding of S. epidermidis strain diversity, skin colonization dynamics and its multifaceted interactions with the host and other members of the skin microbiota.

Indexed as

MicrobiotaStaphylococcal InfectionsBiofilmsHumansSkinStaphylococcus epidermidisVirulence

Identifiers

PMID36042296
PMCPMC9903335
OpenAlexW4293701404

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.