Evidence map›Paper›PMID 36042358›Full record

ArticleNature communications2022

Adipocytes control food intake and weight regain via Vacuolar-type H

Rizaldy C Zapata, Maria Carretero, Felipe Castellani Gomes Reis, Besma S Chaudry, Jachelle Ofrecio, Dinghong Zhang, Roman Sasik, Theodore Ciaraldi, Michael Petrascheck, Olivia Osborn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rizaldy C ZapataDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Maria CarreteroDepartment of Molecular Medicine and Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Felipe Castellani Gomes ReisDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-8357-5261
Besma S ChaudryDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-0340-3270
Jachelle OfrecioDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Dinghong ZhangDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-6291-0750
Roman SasikCenter for Computational Biology & Bioinformatics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Theodore CiaraldiDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Michael PetrascheckDepartment of Molecular Medicine and Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0002-1010-145X
Olivia OsbornDivision of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. oosborn@ucsd.edu.ORCID 0000-0003-0516-7937
University of California San Diego · USScripps Research Institute · US

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
An in vivo screening system for chemical modulators of eating behaviorR01DK117872 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI OSBORN, OLIVIA D, PETRASCHECK, MICHAEL · 2018 to 2022
$2.9M
NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK117872NIH HHS P40 OD010440
6 · The paper itself

Abstract

Energy metabolism becomes dysregulated in individuals with obesity and many of these changes persist after weight loss and likely play a role in weight regain. In these studies, we use a mouse model of diet-induced obesity and weight loss to study the transcriptional memory of obesity. We found that the 'metabolic memory' of obesity is predominantly localized in adipocytes. Utilizing a C. elegans-based food intake assay, we identify 'metabolic memory' genes that play a role in food intake regulation. We show that expression of ATP6v0a1, a subunit of V-ATPase, is significantly induced in both obese mouse and human adipocytes that persists after weight loss. C. elegans mutants deficient in Atp6v0A1/unc32 eat less than WT controls. Adipocyte-specific Atp6v0a1 knockout mice have reduced food intake and gain less weight in response to HFD. Pharmacological disruption of V-ATPase assembly leads to decreased food intake and less weight re-gain. In summary, using a series of genetic tools from invertebrates to vertebrates, we identify ATP6v0a1 as a regulator of peripheral metabolic memory, providing a potential target for regulation of food intake, weight loss maintenance and the treatment of obesity.

Indexed as

Diet, High-FatObesityAdipocytesAnimalsCaenorhabditis elegansEatingHumansMiceMice, Inbred C57BLMice, ObeseVacuolar Proton-Translocating ATPasesWeight GainWeight LossATP6V0A1 protein, mouseVacuolar Proton-Translocating ATPases

Identifiers

PMID36042358
PMCPMC9427743
OpenAlexW4293554400

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.