ArticleThe Lancet. Rheumatology2022
Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study.
Article in The Lancet. Rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals.Human molecular genetics · 2026Pooled it
- Examining the role of insulin-like growth factor 1 in the pathophysiology of carpal tunnel syndrome: a Mendelian randomization study.International journal of epidemiology · 2026Article
- Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Nature communications · 2026Article
- Clinical and demographic factors associated with coexisting carpal tunnel syndrome and trigger finger in Kazakhstan.Orthopedic reviews · 2026Article
- Trigger finger and the risk of systemic inflammatory and autoimmune rheumatic diseases: real-world evidence.Frontiers in immunology · 2026Article
- Evaluation of Endoscopic Release for Carpal Tunnel Syndrome.Plastic and reconstructive surgery. Global open · 2025Article
- Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables.European journal of medical research · 2025Article
- Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies.European journal of medical research · 2025Article
- Systemic low-grade C-reactive protein is associated with proximal symptom spread in carpal tunnel syndrome.Pain reports · 2024Article
- Hyperglycaemia is a causal risk factor for upper limb pathologies.International journal of epidemiology · 2024Article
- Pairwise association of upper extremity musculoskeletal conditions: large population investigation from PERSIAN cohort study.Journal of orthopaedic surgery and research · 2023Article
- Incidence of Carpal Tunnel Syndrome Requiring Surgery May Increase in Patients Treated with Trigger Finger Release: A Retrospective Cohort Study.Clinical epidemiology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Background: Trigger finger and carpal tunnel syndrome are the two most common non-traumatic connective tissue disorders of the hand. Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. However, this phenotypic association is poorly understood. Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases. Methods: In this genome-wide association study (GWAS), we identified 2908 patients with trigger finger and 436579 controls from the UK Biobank prospective cohort. We conducted a case-control GWAS for trigger finger, followed by co-localisation analyses with carpal tunnel syndrome summary statistics. To identify putative causal variants and establish their biological relevance, we did fine-mapping analyses and expression quantitative trait loci (eQTL) analyses, using fibroblasts from healthy donors (n=79) and tenosynovium samples from patients with carpal tunnel syndrome (n=77). We conducted a Cox regression for time to trigger finger and carpal tunnel syndrome diagnosis against plasma IGF-1 concentrations in the UK Biobank cohort. Findings: Phenome-wide analyses confirmed a marked association between carpal tunnel syndrome and trigger finger in the participants from UK Biobank (odds ratio [OR] 11·97, 95% CI 11·1-13·0; p<1 × 10 Interpretation: In this GWAS, the Funding: Wellcome Trust, National Institute for Health Research, Medical Research Council.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.