Evidence map›Paper›PMID 36044173›Full record

ArticleInvestigational new drugs2022

Combination of ruxolitinib with ABT-737 exhibits synergistic effects in cells carrying concurrent JAK2

Jiajia Yuan, Junzhe Song, Chao Chen, Xue Lv, Jie Bai, Jing Yang, Yuan Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jiajia YuanState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Junzhe SongState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Chao ChenState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Xue LvState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Jie BaiDepartment of Hematology, the Second Hospital of Tianjin Medical University, Tianjin, China.
Jing YangDepartment of Pathology and Pathophysiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China. yjphy@126.com.
Yuan ZhouState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. yuanzhou@ihcams.ac.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNHangzhou Normal University · CNInstitute of Hematology & Blood Diseases Hospital · CNTianjin Medical University · CN

Funding

Key Project of Science and Technology Research Project of Hebei Universities ZD2021069National Key Research and Development Program of China 2020YFE0203000National Natural Science Foundation of China 81770128National Natural Science Foundation of China 81900249National Natural Science Foundation of China 81970120Natural Science Foundation of Hebei Province H2020206003
6 · The paper itself

Abstract

The V617F mutation in Janus kinase 2 is considered one of the driver mutations leading to Philadelphia-negative myeloproliferative neoplasms (MPNs). Concurrent JAK2

Indexed as

Janus Kinase 2Myeloproliferative DisordersBiphenyl CompoundsHumansMutationNitrilesNitrophenolsPiperazinesPyrazolesPyrimidinesRepressor ProteinsSulfonamidesABT-737ASXL1 protein, humanBiphenyl CompoundsJAK2 protein, humanJanus Kinase 2NitrilesNitrophenolsPiperazinesPyrazolesPyrimidinesRepressor ProteinsruxolitinibSulfonamidesApoptosisBCL2 inhibitorMPNRuxolitinib

Identifiers

PMID36044173
OpenAlexW4293767591

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.