Evidence map›Paper›PMID 36044573›Full record

ArticleScience advances2022

Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2.

Kenny Mattonet, Fréderike W Riemslagh, Stefan Guenther, Karin D Prummel, Gokul Kesavan, Stefan Hans, Ingo Ebersberger, Michael Brand, Alexa Burger, Sven Reischauer and 2 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. CRISPR-based functional genomics tools in vertebrate models.Experimental & molecular medicine · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Science advances · 2024
    Article
  8. Science advances · 2024
    Article
  9. Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. bioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kenny MattonetDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany.ORCID 0000-0002-9705-8086
Fréderike W RiemslaghSection of Developmental Biology, Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 E 17th Avenue, Aurora, CO 80045, USA.ORCID 0000-0002-8530-3339
Stefan GuentherDZHK (German Center for Cardiovascular Research), partner site, 43, D-61231 Bad Nauheim.ORCID 0000-0002-5594-4549
Karin D PrummelSection of Developmental Biology, Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 E 17th Avenue, Aurora, CO 80045, USA.ORCID 0000-0001-6077-6407
Gokul KesavanCenter for Regenerative Therapies at TU Dresden (CRTD); Dresden, Germany.ORCID 0000-0002-2828-1460
Stefan HansCenter for Regenerative Therapies at TU Dresden (CRTD); Dresden, Germany.ORCID 0000-0003-0283-0211
Ingo EbersbergerGoethe University Frankfurt am Main, Institute of Cell Biology and Neuroscience, Frankfurt 60438, Germany.ORCID 0000-0001-8187-9253
Michael BrandCenter for Regenerative Therapies at TU Dresden (CRTD); Dresden, Germany.ORCID 0000-0001-5711-6512
Alexa BurgerSection of Developmental Biology, Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 E 17th Avenue, Aurora, CO 80045, USA.ORCID 0000-0001-7137-3910
Sven ReischauerDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany.ORCID 0000-0002-6955-9481
Christian MosimannSection of Developmental Biology, Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 E 17th Avenue, Aurora, CO 80045, USA.ORCID 0000-0002-0749-2576
Didier Y R StainierDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany.ORCID 0000-0002-0382-0026

Funding

Developmental causes of syndromic Thrombocytopenia and co-morbiditiesR01DK129350 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURGER, ALEXA · 2022 to 2024
$690k
NIDDK NIH HHS R01 DK129350
6 · The paper itself

Abstract

Endothelial specification is a key event during embryogenesis; however, when, and how, endothelial cells separate from other lineages is poorly understood. In zebrafish, Npas4l is indispensable for endothelial specification by inducing the expression of the transcription factor genes

Identifiers

PMID36044573
PMCPMC9432843

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.