Evidence map›Paper›PMID 36044865›Full record

ArticleCell reports2022

Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection.

Elliott D SoRelle, Joanne Dai, Nicolás M Reinoso-Vizcaino, Ashley P Barry, Cliburn Chan, Micah A Luftig

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 55 citations in OpenAlex.

  1. A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Reconstructing EBV reactivation and DNA damage response kinetics in morphologic pseudotime.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
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  9. Review
  10. Review
  11. LANA-specific CD4Nature communications · 2025
    Article
  12. EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND TbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elliott D SoRelleDepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: elliott.sorelle@duke.edu.
Joanne DaiDepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University School of Medicine, Durham, NC 27710, USA.
Nicolás M Reinoso-VizcainoDepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University School of Medicine, Durham, NC 27710, USA.
Ashley P BarryDepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University School of Medicine, Durham, NC 27710, USA.
Cliburn ChanDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA.
Micah A LuftigDepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: micah.luftig@duke.edu.
Duke University · US

Funding

Viral Oncology Training GrantT32CA009111 · NCI · DUKE UNIVERSITY · PI LUFTIG, MICAH A. · 1985 to 2023
$8.9M
Targeting Apoptosis and Immune Control of Epstein-Barr Virus Infected Tonsillar B CellsR01DE025994 · NIDCR · DUKE UNIVERSITY · PI Micah Alan Luftig · 2016 to 2026
$5.0M
The role of EBNA3A in the survival of Epstein-Barr Virus-infected tonsillar B cellsF31DE027875 · NIDCR · DUKE UNIVERSITY · PI DAI, JOANNE · 2018 to 2019
$72k
NCI NIH HHS T32 CA009111NIDCR NIH HHS F31 DE027875NIDCR NIH HHS R01 DE025994
6 · The paper itself

Abstract

Epstein-Barr virus infection of B lymphocytes elicits diverse host responses via well-adapted transcriptional control dynamics. Consequently, this host-pathogen interaction provides a powerful system to explore fundamental processes leading to consensus fate decisions. Here, we use single-cell transcriptomics to construct a genome-wide multistate model of B cell fates upon EBV infection. Additional single-cell data from human tonsils reveal correspondence of model states to analogous in vivo phenotypes within secondary lymphoid tissue, including an EBV

Indexed as

Epstein-Barr Virus InfectionsB-LymphocytesHerpesvirus 4, HumanHost-Pathogen InteractionsHumansTranscriptomeatypical memory B cellsB-cell differentiationB cellscell fatecell reprogrammingCP: Immunologyearly memory B cellsEpstein-Barr virusgerminal centerscRNA-seqviral oncology

Identifiers

PMID36044865
PMCPMC9879279
OpenAlexW4293574523

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.