Evidence map›Paper›PMID 36045118›Full record

ArticleNature communications2022

OXTR

Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Cytokines and cancer-associated fibroblasts.Journal of hematology & oncology · 2026
    Review
  7. Article
  8. Article
  9. Serum metabolomics identifies biomarkers in radicular cysts.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. HAS1Journal of experimental & clinical cancer research : CR · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. The immunological landscape of CCL26Frontiers in cell and developmental biology · 2025
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Liang DingCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.ORCID 0000-0002-1043-0923
Yong FuCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Nisha ZhuCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.ORCID 0000-0001-8328-0025
Mengxiang ZhaoCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Zhuang DingCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Xiaoxin ZhangCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Yuxian SongCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Yue JingCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Qian ZhangDepartment of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China.
Sheng ChenDepartment of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Xiaofeng HuangDepartment of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China.
Lorraine A O'ReillyThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID 0000-0001-7134-6496
John SilkeThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID 0000-0002-7611-5774
Qingang HuCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China. qghu@nju.edu.cn.ORCID 0000-0001-8325-9488
Yanhong NiCentral Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, Jiangsu, China. niyanhong12@163.com.ORCID 0000-0002-3890-3884
Nanjing University · CNNanjing Medical University · CNThe University of Melbourne · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pattern Of Invasion (POI) of tumor cells into adjacent normal tissues clinically predicts postoperative tumor metastasis/recurrence of early oral squamous cell carcinoma (OSCC), but the mechanisms underlying the development of these subtypes remain unclear. Focusing on the highest score of POIs (Worst POI, WPOI) present within each tumor, we observe a disease progression-driven shift of WPOI towards the high-risk type 4/5, associated with a mesenchymal phenotype in advanced OSCC. WPOI 4-5-derived cancer-associated fibroblasts (CAFs

Indexed as

Head and Neck NeoplasmsMitogen-Activated Protein Kinase 7Mouth NeoplasmsSquamous Cell Carcinoma of Head and NeckCarcinoma, Squamous CellCell Line, TumorFibroblastsHumansNeoplasm InvasivenessReceptors, OxytocinMAPK7 protein, humanMitogen-Activated Protein Kinase 7OXTR protein, humanReceptors, Oxytocin

Identifiers

PMID36045118
PMCPMC9433374
OpenAlexW4293747331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.