Evidence map›Paper›PMID 36048753›Full record

ArticleAutophagy2023

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury.

Thomas J Krzystek, Joseph A White, Rasika Rathnayake, Layne Thurston, Hayley Hoffmar-Glennon, Yichen Li, Shermali Gunawardena

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas J KrzystekDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Joseph A WhiteDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Rasika RathnayakeDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Layne ThurstonDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Hayley Hoffmar-GlennonDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Yichen LiDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.
Shermali GunawardenaDepartment of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0001-8776-9397
University at Buffalo, State University of New York · US

Funding

Dissecting the in vivo role of glycogen synthase kinase-3 beta (GSK3b) in the function of kinesin-1 using CRISPR/cas-1R03NS114731 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GUNAWARDENA, SHERMALI · 2020 to 2020
$157k
A synthetic vesicle to carry modifier compounds to axonal blocks induced by pathogenic polyQR03NS092024 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GUNAWARDENA, SHERMALI · 2015 to 2016
$156k
Dissecting the in vivo role of Huntingtin in Rab vesicle movement on microtubulesR03NS084386 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GUNAWARDENA, SHERMALI · 2013 to 2014
$155k
NINDS NIH HHS R03 NS084386NINDS NIH HHS R03 NS092024NINDS NIH HHS R03 NS114731
6 · The paper itself

Abstract

abbreviationsAtg5: Autophagy-related 5; Atg8a: Autophagy-related 8a; AL: autolysosome; AP: autophagosome; BAF1: bafilomycin A

Indexed as

AutophagyKinesinsAxonsCarrier ProteinsEndosomesHumansHuntingtin ProteinLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMitogen-Activated Protein Kinase 8Transcription FactorsCarrier ProteinsHTT protein, humanHuntingtin ProteinKIF5C protein, humanKinesinsLAMP1 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMitogen-Activated Protein Kinase 8Transcription FactorsAxonal injuryaxonal transportDrosophilaendolysosomeshuntingtinsignaling endosome

Identifiers

PMID36048753
PMCPMC10012955
OpenAlexW4294043815

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.