Evidence map›Paper›PMID 36048786›Full record

SynthesisPloS one2022

Glycemic index, glycemic load, and lung cancer risk: A meta-analysis of cohort and case-control studies.

Hongzhen Du, Tianfeng Zhang, Xuning Lu, Meicui Chen, Xiaoling Li, Zengning Li

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hongzhen DuDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Tianfeng ZhangDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xuning LuDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Meicui ChenDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xiaoling LiDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Zengning LiDepartment of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID 0000-0002-0915-6541
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGlycemic index (GI) or glycemic load (GL) has been investigated in the field of cancer research for several years. However, the relationship between GI or GL and lung cancer risk remains inconsistent. Therefore, this study aimed to summarize previous findings on this relationship.

methodsPubMed, Embase, Scopus, Web of Science databases, and Cochrane Library were searched by July 2021. This review was conducted in accordance with the PRISMA guidelines. A fixed or random-effects model was adopted for meta-analysis to compute the pooled relative risks (RR) and their corresponding 95% confidence intervals (CIs). Subgroup analyses, sensitivity analyses, and publication bias analyses were also performed.

resultsIn total, nine articles were included, with four case-control studies and five cohort studies, including 17,019 cases and 786,479 controls. After merging the studies, pooled multivariable RRs of lung cancer based on the highest versus the lowest intake were 1.14 (95%CI: 1.03-1.26) and 0.93 (95%CI: 0.84-1.02) for GI and GL. Results persisted in most stratifications after stratifying by potential confounders in the relationship between GI and lung cancer risk. There was a non-linear dose response relation for GI with lung caner risk.

conclusionGI typically has a positive relationship with lung cancer risk. However, no associations between GL and lung cancer risk were observed based on current evidence, suggesting that this issue should be studied and verified further to substantiate these findings.

Indexed as

Glycemic LoadLung NeoplasmsCase-Control StudiesCohort StudiesDietDietary CarbohydratesGlycemic IndexHumansLungRisk FactorsDietary Carbohydrates

Identifiers

PMID36048786
PMCPMC9436153
OpenAlexW4294044323

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.