ArticleScience (New York, N.Y.)2022
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers.
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Who cites it
189 citing papers in PubMed, 286 citations in OpenAlex.
- Mapping Brain Spatial Metabolic Atlas Reveals Anesthesia-Induced Region-Specific Alterations.Neuroscience bulletin · 2026Article
- Single-cell and spatial RNA sequencing in prostate cancer.Nature reviews. Urology · 2026Review
- RKMR: A Rapid Kernel Machine Regression Framework for Optimal Marker Detection in Spatial Omics Data.bioRxiv : the preprint server for biology · 2026Article
- A High-Resolution Stereo-Seq Spatial Transcriptomic Resource for Adult Holstein Cattle Liver.International journal of molecular sciences · 2026Article
- cGAS-STING pathway modulation: A new hope for neural regeneration.Neural regeneration research · 2026Article
- Tenascin C-Derived Peptide 6 Promotes De Novo Kidney Regeneration after Partial Nephrectomy in Axolotl.Journal of the American Society of Nephrology : JASN · 2026Article
- Molecular Mechanisms of Age-Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics.Aging cell · 2026Article
- OT-knn: A neighborhood-aware optimal transport framework for aligning spatial transcriptomics data.PLoS computational biology · 2026Article
- Lessons from the Axolotl: De Novo Nephron Formation after Nephrectomy.Journal of the American Society of Nephrology : JASN · 2026Article
- Spatial Transcriptomics-Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication.Advanced healthcare materials · 2026Article
- Benchmarking cell type annotation in spatial transcriptomics: resolving cellular hierarchies, biological fidelity, and dynamic cell states.Research square · 2026Article
- Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons.Stem cell reports · 2026Article
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- The brain-limb axis: Elucidating CNS mediators of salamander limb regeneration.Current opinion in neurobiology · 2026Review
- DESpace2: detection of differential spatial patterns in spatial omics data.Bioinformatics (Oxford, England) · 2026Article
- Regeneration of the mammalian brain: a relic of evolution?Stem cells (Dayton, Ohio) · 2026Review
- Dissecting human organ development using spatial technologies.Developmental cell · 2026Review
- A 3D amphioxus brain atlas illuminates the blueprint of the ancestral chordate brain and highlights unique vertebrate innovations.Science advances · 2026Article
- Structural-information guided fusion for spatial domain identification from spatial transcriptomics.Bioinformatics (Oxford, England) · 2026Article
- A dependency-aware deep generative model for inferring RNA velocity from spatial transcriptomics.Bioinformatics (Oxford, England) · 2026Article
129 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially resolved single-cell transcriptomes of axolotl telencephalon sections during development and regeneration. Annotated cell types exhibited distinct spatial distribution, molecular features, and functions. We identified an injury-induced ependymoglial cell cluster at the wound site as a progenitor cell population for the potential replenishment of lost neurons, through a cell state transition process resembling neurogenesis during development. Transcriptome comparisons indicated that these induced cells may originate from local resident ependymoglial cells. We further uncovered spatially defined neurons at the lesion site that may regress to an immature neuron-like state. Our work establishes spatial transcriptome profiles of an anamniote tetrapod brain and decodes potential neurogenesis from ependymoglial cells for development and regeneration, thus providing mechanistic insights into vertebrate brain regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.