Evidence map›Paper›PMID 36048957›Full record

ArticleScience (New York, N.Y.)2022

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution.

Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere, Eliza C B Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D Leigh, Maximina Yun and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Article
  3. Neural correlates of spatial orientation in a territorial frog Allobates femoralis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. A conserved logic for the development of cortical layering in tetrapods.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Jamie Woych *Department of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-3922-6264
Alonso Ortega Gurrola *Department of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-9223-7897
Astrid Deryckere *Department of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-6227-7759
Eliza C B Jaeger *Department of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0003-3708-7923
Elias Gumnit *Department of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0003-2195-0665
Gianluca MerelloDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-3317-6198
Jiacheng GuDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Alberto Joven ArausDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-0926-4665
Nicholas D LeighMolecular Medicine and Gene Therapy, Wallenberg Centre for Molecular Medicine, Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden.ORCID 0000-0002-6978-6254
Maximina YunTechnische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, 01307 Dresden, Germany.ORCID 0000-0001-9019-2453
András SimonDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Maria Antonietta ToschesDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-6338-9357
Columbia University · USKarolinska Institutet · SELund University · SEMax Planck Institute of Molecular Cell Biology and Genetics · DE

Funding

Center for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1M
Core Research Computing FacilityG20RR030893 · NCRR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PURDY, MICHAEL · 2010 to 2010
$10.0M
A multi-wavelength lighsheet microscope for volumetric imagingS10OD023587 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PETERKA, DARCY S · 2017 to 2017
$236k
NCRR NIH HHS G20 RR030893NHGRI NIH HHS RM1 HG011014NIH HHS S10 OD023587
6 · The paper itself

Abstract

The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander

Indexed as

Biological EvolutionNeuronsPleurodelesTelencephalonAnimalsAtlases as TopicNeocortexTranscriptome

Identifiers

PMID36048957
PMCPMC10024926
OpenAlexW4294073634

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.