Evidence map›Paper›PMID 36049528›Full record

ArticleLife sciences2022

Modulation of cardiac voltage-activated K

Diego Santos Souza, Andreia Zago Chignalia, Joao Luis Carvalho-de-Souza

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Diego Santos SouzaDepartment of Anesthesiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Andreia Zago ChignaliaDepartment of Anesthesiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA; Department of Physiology, College of Medicine University of Arizona, Tucson, AZ 85724, USA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
Joao Luis Carvalho-de-SouzaDepartment of Anesthesiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA; Department of Physiology, College of Medicine University of Arizona, Tucson, AZ 85724, USA; Department of Ophthalmology and Visual Sciences, College of Medicine, University of Arizona, Tucson, AZ 85724, USA; BIO5 Institute, University of Arizona, Tucson, AZ 85724, USA. Electronic address: jcds@anesth.arizona.edu.
University of Arizona · US

Funding

American Heart Association-American Stroke Association 850700
6 · The paper itself

Abstract

backgroundGlypican 1 (Gpc1) is a heparan sulfate proteoglycan attached to the cell membrane via a glycosylphosphatidylinositol anchor, where it holds glycosaminoglycans nearby. We have recently shown that Gpc1 knockout (Gpc1

methodsWe used echocardiography and in vivo (electrocardiographic recordings) and in vitro (patch clamping) electrophysiology to study mechanical and electric properties of mice hearts. We used RT-PCR to probe K

resultsGpc1

conclusionOur data reveals an unprecedented connection between Gpc1 and voltage-gated K

Indexed as

Heparan Sulfate ProteoglycansPotassium Channels, Voltage-GatedAction PotentialsAnimalsArrhythmias, CardiacGlycosylphosphatidylinositolsGlypicansKCNQ1 Potassium ChannelMiceMyocytes, CardiacPotassium ChannelsGlycosylphosphatidylinositolsGlypicansHeparan Sulfate ProteoglycansKCNQ1 Potassium ChannelPotassium ChannelsPotassium Channels, Voltage-GatedDelayed rectifiersGlypican 1HypertensionLong QT (LQT)Protein-protein interactionTransient outward currentVoltage-activated K(+) currents

Identifiers

PMID36049528
PMCPMC11105158
OpenAlexW4293530287

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.