Evidence map›Paper›PMID 36050586›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2022

Barriers and Facilitators to the Initiation of Injectable Therapies for Type 2 Diabetes Mellitus: A Mixed Methods Study.

Simon de Lusignan, Andrew McGovern, William Hinton, Martin Whyte, Neil Munro, Emily D Williams, Afrodita Marcu, John Williams, Filipa Ferreira, Julie Mount and 4 more

Open access · goldAbstract read
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effects on HbA1c of referral of type 2 diabetes patients to secondary care.Scandinavian journal of primary health care · 2025
    Article
  5. Article
  6. Article
  7. Therapeutic Inertia in the Management of Type 2 Diabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Simon de LusignanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. simon.delusignan@phc.ox.ac.uk.ORCID http://orcid.org/0000-0002-8553-2641
Andrew McGovernDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-6833-9399
William HintonNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4927-0901
Martin WhyteDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
Neil MunroDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0003-0150-326X
Emily D WilliamsSchool of Health Sciences, University of Surrey, Guildford, UK.
Afrodita MarcuSchool of Health Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-5918-3417
John WilliamsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Filipa FerreiraNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7717-8486
Julie MountEli Lilly and Company, Basingstoke, Hampshire, UK.ORCID http://orcid.org/0000-0003-2185-151X
Manasa TripathyNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Emmanouela KonstantaraDepartment of Diabetes, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7205-285X
Benjamin C T FieldDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-1883-1588
Michael FeherNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0631-6199
University of Surrey · GBEast Surrey Hospital · GBEli Lilly (United Kingdom) · GBKing's College London · GBUniversity of Exeter · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInitiation of injectable therapies in type 2 diabetes (T2D) is often delayed, however the reasons why are not fully understood.

methodsA mixed methods study performed in sequential phases. Phase 1: focus groups with people with T2D (injectable naïve [n = 12] and experienced [n = 5]) and healthcare professionals (HCPs; nurses [n = 5] and general practitioners (GPs) [n = 7]) to understand their perceptions of factors affecting initiation of injectables. Phase 2: video-captured GP consultations (n = 18) with actor-portrayed patient scenarios requiring T2D treatment escalation to observe the initiation in the clinical setting. Phase 3: HCP surveys (n = 87) to explore external validity of the themes identified in a larger sample.

resultsFocus groups identified patients' barriers to initiation; fear, lack of knowledge and misconceptions about diabetes and treatment aims, concerns regarding lifestyle restrictions and social stigma, and feelings of failure. Facilitators included education, good communication, clinician support and competence. HCP barriers included concerns about weight gain and hypoglycaemia, and limited consultation time. In simulated consultations, GPs performed high-quality consultations and recognised the need for injectable initiation in 9/12 consultations where this was the expert recommended option but did not provide support for initiation themselves. Survey results demonstrated HCPs believe injectable initiation should be performed in primary care, although many practitioners reported inability to do so or difficulty in maintaining skills.

conclusionPeople with T2D have varied concerns and educational needs regarding injectables. GPs recognise the need to initiate injectables but lack practical skills and time to address patient concerns and provide education. Primary care nurses also report difficulties in maintaining these skills. Primary care HCPs initiating injectables require additional training to provide practical demonstrations, patient education and how to identify and address concerns. These skills should be concentrated in the hands of a small number of primary care providers to ensure they can maintain their skills.

Indexed as

BarriersDiabetes mellitus, type 2GLP1 receptor analoguesInitiationInsulinMedical record systems, computerizedMixed methodsPrimary care

Identifiers

PMID36050586
PMCPMC9500132
OpenAlexW4294147814

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.