Evidence map›Paper›PMID 36052553›Full record

ArticleZoological research2022

General mechanism of spider toxin family I acting on sodium channel Nav1.7.

Fu-Chu Yuan, Fu-De Sun, Lin Zhang, Biao Huang, Hai-Long An, Ming-Qiang Rong, Can-Wei Du

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Tick-Derived Peptide Blocks Potassium Channel TREK-1.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fu-Chu YuanNational & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410006, China.
Fu-De SunKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China.
Lin ZhangNational & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410006, China.
Biao HuangChengdu Pepbiomedical Co., Ltd., Chengdu, Sichuan 610219, China.
Hai-Long AnKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China.
Ming-Qiang RongNational & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410006, China. E-mail: rongmq@hunnu.edu.cn.
Can-Wei DuChengdu Pepbiomedical Co., Ltd., Chengdu, Sichuan 610219, China. E-mail: ducw2022@163.com.
Hunan Normal University · CNHebei University of Technology · CNChengdu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin (NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., N-terminal, loops 1-4, and C-terminal. Here, we used Mu-theraphotoxin-Ca2a (Ca2a), a peptide isolated from

Indexed as

Spider VenomsAnimalsPeptidesSodium ChannelsVoltage-Gated Sodium Channel BlockersPeptidesSodium ChannelsSpider VenomsVoltage-Gated Sodium Channel BlockersICK motifNav1.7Peptide toxinSpider

Identifiers

PMID36052553
PMCPMC9486512
OpenAlexW4294151223

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.