ArticleAnnals of neurology2023
Association of Cortical Superficial Siderosis with Post-Stroke Epilepsy.
Article in Annals of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Research landscape and trends of cerebral amyloid angiopathy: a 25-year scientometric analysis.Frontiers in neurology · 2023Pooled it
- Association Between Multiple Inflammation-Derived Indices and the Risk of Post-Stroke Epilepsy.CNS neuroscience & therapeutics · 2026Article
- Incidence of Early and In-hospital Late Seizures Following Aneurysmal Subarachnoid Hemorrhage in Patients Treated with Clazosentan: A Multicenter Retrospective Cohort Study.Neurologia medico-chirurgica · 2026Article
- Characterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication.PloS one · 2026Article
- Angiographic signs during mechanical thrombectomy as predictors of post-stroke epilepsy: a multicenter retrospective study.Journal of neurointerventional surgery · 2025Article
- Neuroprotective Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib Against Caspase-1-dependent Pyroptosis Partially by Suppressing the HMGB1/TLR4 Pathway.Cellular and molecular neurobiology · 2025Article
- Prediction of late seizures after ischemic stroke using cognitive scores.BMC neurology · 2025Article
- Classical type of superficial hemosiderosis presenting with temporal lobe epilepsy.Surgical neurology international · 2025Article
- Pathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy: Clinical and Research Implications.Neurology · 2024Review
- Prevalence of Cerebral Amyloid Angiopathy Pathology and Strictly Lobar Microbleeds in East-Asian Versus Western Populations: A Systematic Review and Meta-Analysis.Journal of stroke · 2024Review
- Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage.Neurologia medico-chirurgica · 2024Article
- Clinical Biomarkers and Prediction Models for Poststroke Epilepsy: Have We Settled the Scores Yet?Neurology. Clinical practice · 2023Article
- Editorial: Epilepsy and dementia in stroke survivors.Frontiers in neurology · 2023Article
- A machine learning model for predicting post-stroke epilepsy risk by integrating multimodal EEG-fMRI and clinical biomarkers.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether post-stroke epilepsy (PSE) is associated with neuroimaging findings of hemosiderin in a case-control study, and whether the addition of hemosiderin markers improves the risk stratification models of PSE.
methodsWe performed a post-hoc analysis of the PROgnosis of POST-Stroke Epilepsy study enrolling PSE patients at National Cerebral and Cardiovascular Center, Osaka, Japan, from November 2014 to September 2019. PSE was diagnosed when one unprovoked seizure was experienced >7 days after the index stroke, as proposed by the International League Against Epilepsy. As controls, consecutive acute stroke patients with no history or absence of any late seizure or continuing antiseizure medications at least 3 months after stroke were retrospectively enrolled during the same study period. We examined cortical microbleeds and cortical superficial siderosis (cSS) using gradient-echo T2*-weighted images. A logistic regression model with ridge penalties was tuned using 10-fold cross-validation. We added the item of cSS to the existing models (SeLECT and CAVE) for predicting PSE and evaluated performance of new models.
resultsThe study included 180 patients with PSE (67 women; median age 74 years) and 1,183 controls (440 women; median age 74 years). The cSS frequency was higher in PSE than control groups (48.9% vs 5.7%, p < 0.0001). Compared with the existing models, the new models with cSS (SeLECT-S and CAVE-S) demonstrated significantly better predictive performance of PSE (net reclassification improvement 0.63 [p = 0.004] for SeLECT-S and 0.88 [p = 0.001] for CAVE-S at the testing data).
interpretationCortical superficial siderosis was associated with PSE, stratifying stroke survivors at high risk of PSE. ANN NEUROL 2023;93:357-370.
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