Evidence map›Paper›PMID 36055650›Full record

ReviewAnnual review of genetics2022

The Four Causes: The Functional Architecture of Centromeres and Kinetochores.

Andrew D McAinsh, Adele L Marston

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. HOROSCOPE: Decoding human centromere architecture from short reads usingbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Structure and dynamics of 2x(CENP-A/H4)Life science alliance · 2026
    Article
  8. Review
  9. Article
  10. Kinetochore components are perinuclear and form condensates inbioRxiv : the preprint server for biology · 2025
    Article
  11. Revisiting the question: When is a centromere not a kinetochore?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Non-nucleosomal (CENP-A/H4)bioRxiv : the preprint server for biology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew D McAinshCentre for Mechanochemical Cell Biology, University of Warwick, Coventry, United Kingdom; email: A.D.McAinsh@warwick.ac.uk.
Adele L MarstonThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom; email: adele.marston@ed.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/R009503/1Wellcome Trust 106151Wellcome Trust 203149Wellcome Trust 215625Wellcome Trust 220780
6 · The paper itself

Abstract

Kinetochores are molecular machines that power chromosome segregation during the mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have knowledge of a thing only when we have grasped its cause. In our case, to gain understanding of the kinetochore, the four causes correspond to questions that we must ask: (

Indexed as

CentromereKinetochoresChromatinChromosome SegregationMicrotubulesChromatincell divisioncentromerechromatinchromosomekinetochoremeiosismicrotubulemitosismitotic spindle

Identifiers

PMID36055650
PMCPMC7614391

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.