Evidence map›Paper›PMID 36055772›Full record

ArticleThe American journal of clinical nutrition2022

Research gaps and opportunities in precision nutrition: an NIH workshop report.

Bruce Y Lee, José M Ordovás, Elizabeth J Parks, Cheryl A M Anderson, Albert-László Barabási, Steven K Clinton, Kayla de la Haye, Valerie B Duffy, Paul W Franks, Elizabeth M Ginexi and 25 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
  8. The Role of Precision Nutrition in Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  9. Review
  10. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Advancing personalised and precision nutrition.Journal of nutritional science · 2026
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 7 countries.

Bruce Y LeeHealth Policy and Management, City University of New York Graduate School of Public Health and Health Policy, New York, NY, USA.
José M OrdovásUSDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Elizabeth J ParksNutrition and Exercise Physiology, University of Missouri School of Medicine, MO, USA.
Cheryl A M AndersonPublic Health, University of California, San Diego, San Diego, CA, USA.
Albert-László BarabásiNetwork Science Institute and Department of Physics, Northeastern University, Boston, MA, USA.
Steven K ClintonThe Ohio State University, Columbus, OH, USA.
Kayla de la HayeKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Valerie B DuffyAllied Health Sciences, University of Connecticut, Storrs, CT, USA.
Paul W FranksNovo Nordisk Foundation, Hellerup, Denmark, Copenhagen, Denmark, and Lund University Diabetes Center, Sweden.
Elizabeth M GinexiNational Institutes of Health, Office of Behavioral and Social Sciences Research, Bethesda, MD, USA.
Kristian J HammondComputer Science, Northwestern University McCormick School of Engineering, IL, USA.
Erin C HanlonDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Michael HittleEpidemiology and Clinical Research, Stanford University, Stanford, CA, USA.
Emily HoPublic Health and Human Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Abigail L HornInformation Sciences Institute, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Richard S IsaacsonNeurology, Weill Cornell Medical College, New York, NY, USA.
Patricia L MabryHealthPartners Institute, Bloomington, MN, USA.ORCID 0000-0002-6374-8679
Susan MaloneRory Meyers College of Nursing, New York University, New York, NY, USA.
Corby K MartinIngestive Behavior Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Josiemer MatteiNutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-5424-8245
Simin Nikbin MeydaniUSDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Lorene M NelsonEpidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9813-8088
Marian L NeuhouserFred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-3876-0000
Brendan ParentGrossman School of Medicine, New York University, New York, NY, USA.
Nicolaas P PronkHealthPartners Institute, Bloomington, MN, USA.ORCID 0000-0002-5825-6733
Helen M RocheUCD Conway Institute, School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Dublin, Ireland.ORCID 0000-0002-0628-3318
Suchi SariaJohns Hopkins University, Baltimore, MD, USA.
Frank A J L ScheerBrigham and Women's Hospital, Boston, MA, USA.
Eran SegalComputer Science and Applied Math, Weizmann Institute of Science, Rehovot, Israel.
Mary Ann SevickGrossman School of Medicine, New York University, New York, NY, USA.
Tim D SpectorTwin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Linda Van HornPreventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Krista A VaradyKinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Venkata Saroja VorugantiNutrition and Nutrition Research Institute, Gillings School of Public Health, The University of North Carolina, Chapel Hill, NC, USA.
Marie F MartinezHealth Policy and Management, City University of New York Graduate School of Public Health and Health Policy, New York, NY, USA.
New York University · USCity University of New York · USHealthPartners · USNorthwestern University · USTufts University · USUniversity of Southern California · USBrigham and Women's Hospital · USCenter for Clinical Research (United States) · USCornell University · USFred Hutch Cancer Center · USHarvard University · USJohns Hopkins University · USKing's College London · GBLund University · SENational Institutes of Health · USNortheastern University · USNutrition 21 (United States) · USNutrition Sciences (Belgium) · BEOregon Department of Human Services · USPennington Biomedical Research Center · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Elizabeth J Mayer-Davis · 1999 to 2026
$31.6M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Project 4: Virtual Public Health Precision Nutrition LaboratoryU54TR004279 · NCATS · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · PI Bruce Y Lee · 2022 to 2026
$5.4M
Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health ResearchT32HL151323 · NHLBI · STANFORD UNIVERSITY · PI Michelle Christina Odden, David H Rehkopf · 2020 to 2026
$1.6M
ANDROGEN REGULATION OF GONADOTROPIN GENE EXPRESSIONF32HD008686 · NICHD · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SPADY, THOMAS J · 2000 to 2001
$61k
NCATS NIH HHS U54 TR004279NHLBI NIH HHS 5T32HL151323-02NHLBI NIH HHS T32 HL151323NICHD NIH HHS F32 HD008686NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health status, behaviors, social influences, and environmental exposures. On 11-12 January 2021, the National Institutes of Health convened a workshop entitled "Precision Nutrition: Research Gaps and Opportunities" to bring together experts to discuss the issues involved in better understanding and addressing precision nutrition. The workshop proceeded in 3 parts: part I covered many aspects of genetics and physiology that mediate the links between nutrient intake and health conditions such as cardiovascular disease, Alzheimer disease, and cancer; part II reviewed potential contributors to interindividual variability in dietary exposures and responses such as baseline nutritional status, circadian rhythm/sleep, environmental exposures, sensory properties of food, stress, inflammation, and the social determinants of health; part III presented the need for systems approaches, with new methods and technologies that can facilitate the study and implementation of precision nutrition, and workforce development needed to create a new generation of researchers. The workshop concluded that much research will be needed before more precise nutrition recommendations can be achieved. This includes better understanding and accounting for variables such as age, sex, ethnicity, medical history, genetics, and social and environmental factors. The advent of new methods and technologies and the availability of considerably more data bring tremendous opportunity. However, the field must proceed with appropriate levels of caution and make sure the factors listed above are all considered, and systems approaches and methods are incorporated. It will be important to develop and train an expanded workforce with the goal of reducing health disparities and improving precision nutritional advice for all Americans.

Indexed as

Evidence GapsNutritional StatusDietHumansNational Institutes of Health (U.S.)NutrigenomicsPrecision MedicineUnited Statesdata sciencefoodgenomicsnutrigenomicsprecision nutrition

Identifiers

PMID36055772
PMCPMC9761773
OpenAlexW4294542431

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.