Evidence map›Paper›PMID 36057845›Full record

ArticleThe Journal of physiology2022

Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.

Sung Jin Hwang, Bernard T Drumm, Min Kyung Kim, Ju Hyeong Lyu, Sal Baker, Kenton M Sanders, Sean M Ward

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  6. Article
  7. Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis.Journal of neurogastroenterology and motility · 2024
    Review
  8. CaPhysiological reviews · 2024
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sung Jin HwangDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Bernard T DrummDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.ORCID 0000-0002-4762-844X
Min Kyung KimDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Ju Hyeong LyuDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Sal BakerDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Kenton M SandersDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.ORCID 0000-0002-4196-1583
Sean M WardDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.ORCID 0000-0003-0217-1535
University of Nevada, Reno · US

Funding

Mechanisms underlying regional differences in gastric compliance in the stomach.R01DK057236 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KENTON M SANDERS, Sean M Ward · 2000 to 2026
$7.1M
Zeiss LSM 510 Laser Scanning Confocal MicroscopeS10RR016871 · NCRR · UNIVERSITY OF NEVADA RENO · PI WARD, SEAN M · 2002 to 2002
$453k
NIDDK NIH HHS R01 DK057236
6 · The paper itself

Abstract

Enteric neurotransmission is critical for coordinating motility throughout the gastrointestinal (GI) tract. However, there is considerable controversy regarding the cells that are responsible for the transduction of these neural inputs. In the present study, utilization of a cell-specific calcium biosensor GCaMP6f, the spontaneous activity and neuroeffector responses of intramuscular ICC (ICC-IM) to motor neural inputs was examined. Simultaneous intracellular microelectrode recordings and high-speed video-imaging during nerve stimulation was used to reveal the temporal relationship between changes in intracellular Ca

Indexed as

Interstitial Cells of CajalAnimalsAtropine DerivativesCalciumCalcium, DietaryGastric FundusMiceMuscarinic AntagonistsNitric Oxide SynthaseSynaptic TransmissionAtropine DerivativesCalciumCalcium, DietaryMuscarinic AntagonistsNitric Oxide Synthasecalcium biosensor GCaMP6fgastric motor activityintracellular Ca2+-transientsIntramuscular ICC (ICC-IM)neuroeffector motor transmission

Identifiers

PMID36057845
PMCPMC12047188
OpenAlexW4294556255

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.