Evidence map›Paper›PMID 36058413›Full record

ArticleThe Journal of infection2022

A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital.

Daniel J Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P Weekes, Ben Warne and 32 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  8. SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 4 institutions in 3 countries.

Daniel J CooperCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Global and Tropical Health Division, Menzies School of Heath Research and Charles Darwin University, Darwin, Northern Territory, Australia; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. Electronic address: Daniel.cooper@addenbrookes.nhs.uk.
Sara LearCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Laura WatsonNIHR Cambridge Clinical Research Facility.
Ashley ShawCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Mark FerrisCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Rainer DoffingerCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Rachel BousfieldCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Katherine SharrocksCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Michael P WeekesCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ben WarneCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Dominic SparkesCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
Nick K JonesCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
Lucy RivettCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
Matthew RoutledgeCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
Afzal ChaudhryCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Katherine DempseyNIHR Cambridge Clinical Research Facility.
Montgomery MatsonUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Adil LakhaUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
George GathercoleUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Olivia O'ConnorUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Emily WilsonUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Orthi ShahzadUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Kieran TomsUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Rachel ThompsonUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Ian HalsallCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
David HalsallCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sally HoughtonCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sofia PapadiaNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Nathalie KingstonNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Kathleen E StirrupsNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Barbara GravesNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Paul TownsendNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Neil WalkerNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Hannah StarkNIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
CITIID-NIHR BioResource COVID-19 Collaboration
Daniela De AngelisMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Shaun SeamanMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Gordon DouganDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
John R BradleyCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
M Estée TörökCambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Ian GoodfellowDepartment of pathology, Division of virology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Stephen BakerDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBNIHR Wellcome Trust Southampton Clinical Research Facility · GBNIHR Cambridge Biomedical Research Centre

Funding

Wellcome Trust 207498Wellcome Trust 207498/Z/17/Z
6 · The paper itself

Abstract

objectivesTo describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs).

methodsWe conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2 immunoassay. Risk factors for seropositivity were analysed using multivariate logistic regression.

results410/5,698 (7·2%) staff tested positive for SARS-CoV-2 antibodies. Seroprevalence was higher in those working in designated COVID-19 areas compared with other areas (9·47% versus 6·16%) Healthcare assistants (aOR 2·06 [95%CI 1·14-3·71]; p=0·016) and domestic and portering staff (aOR 3·45 [95% CI 1·07-11·42]; p=0·039) had significantly higher seroprevalence than other staff groups after adjusting for age, sex, ethnicity and COVID-19 working location. Staff working in acute medicine and medical sub-specialities were also at higher risk (aOR 2·07 [95% CI 1·31-3·25]; p<0·002). Staff from Black, Asian and minority ethnic (BAME) backgrounds had an aOR of 1·65 (95% CI 1·32 - 2·07; p<0·001) compared to white staff; this increased risk was independent of COVID-19 area working. The only symptoms significantly associated with seropositivity in a multivariable model were loss of sense of taste or smell, fever, and myalgia; 31% of staff testing positive reported no prior symptoms.

conclusionsRisk of SARS-CoV-2 infection amongst HCWs is highly heterogeneous and influenced by COVID-19 working location, role, age and ethnicity. Increased risk amongst BAME staff cannot be accounted for solely by occupational factors.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralHealth PersonnelHospitals, TeachingHumansProspective StudiesRisk FactorsSeroepidemiologic StudiesUnited KingdomAntibodies, ViralCOVID-19healthcare workersrisk factor analysisSARS-CoV-2sero-epidemiology

Identifiers

PMID36058413
PMCPMC9436870
OpenAlexW4294191207

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.