Evidence map›Paper›PMID 36059250›Full record

ReviewJournal of cachexia, sarcopenia and muscle2022

D

Cassidy McCarthy, Dale Schoeller, Justin C Brown, M Cristina Gonzalez, Alyssa N Varanoske, Devon Cataldi, John Shepherd, Steven B Heymsfield

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. [Sarcopenia: diagnosis, clinical implications, and treatment].Innere Medizin (Heidelberg, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Leveraging Multiomic Signatures to Predict Body Composition.Advances in nutrition (Bethesda, Md.) · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Fat-Free Mass: Friend or Foe to Metabolic Health?Journal of cachexia, sarcopenia and muscle · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Sarcopenia.Nature reviews. Disease primers · 2024
    Review
  20. Article
4 · The record

Corrections and comments

  • Commented on by
    D2022
5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Cassidy McCarthyPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Los Angeles, USA.
Dale SchoellerBiotechnology Center and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Justin C BrownPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Los Angeles, USA.
M Cristina GonzalezPost-graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil.
Alyssa N VaranoskeMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Devon CataldiUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
John ShepherdUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Steven B HeymsfieldPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Los Angeles, USA.ORCID 0000-0003-1127-9425
Pennington Biomedical Research Center · USUniversity of Hawaiʻi at Mānoa · USUniversidade Católica de Pelotas · BRUniversity of Wisconsin System · USU.S. Army Research Institute of Environmental Medicine · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

The French chemist Michel Eugène Chevreul discovered creatine in meat two centuries ago. Extensive biochemical and physiological studies of this organic molecule followed with confirmation that creatine is found within the cytoplasm and mitochondria of human skeletal muscles. Two groups of investigators exploited these relationships five decades ago by first estimating the creatine pool size in vivo with

Indexed as

CreatineMuscle, SkeletalAthletesChild, PreschoolHumansIndicator Dilution TechniquesMagnetic Resonance ImagingMiddle AgedCreatinebody compositionisotope dilutionmalnutritionnutritional assessment

Identifiers

PMID36059250
PMCPMC9745476
OpenAlexW4294578984

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.