Evidence map›Paper›PMID 36059399›Full record

ArticleComputational intelligence and neuroscience2022

Biological Mechanism on SIRT1/NLRP3/IL-18 Signaling Pathway of Acupuncture for Treatment of Ischemic Stroke with Center Poststroke Pain.

Dan Zhou, Lanfang Zhang, Liwei Mao, Jingyu Cao, Jiaqiang Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational intelligence and neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Dan ZhouClinical Medical College of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lanfang ZhangPhysiotherapy Department, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong, China.ORCID https://orcid.org/0000-0003-1387-1393
Liwei MaoDepartment of Rehabilitation, Guangzhou Tianhe District Chinese Medicine Hospital, Guangzhou, Guangdong 510665, China.
Jingyu CaoDepartment of Rehabilitation, Guangzhou Tianhe District Chinese Medicine Hospital, Guangzhou, Guangdong 510665, China.
Jiaqiang GaoDepartment of Rehabilitation, Guangzhou Tianhe District Chinese Medicine Hospital, Guangzhou, Guangdong 510665, China.
Tianjin Tianhe Hospital · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNGuangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the effect of acupuncture on an animal model of ischemic stroke with central poststroke pain (CPSP) through Sirtuin 1 (SIRT1)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3)/interleukin-18 (IL-18) signaling pathway. Methods: Data mining was performed with Results: The KEGG key pathway map was created using the Conclusion: Acupuncture may inhibit CPSP in an animal model of ischemic stroke by upregulating SIRT1 expression levels, inhibition of the activation of the inflammasome, and downregulating IL-18 expression levels.

Indexed as

Acupuncture TherapyIschemic StrokeAnimalsInflammasomesInterleukin-18NLR Family, Pyrin Domain-Containing 3 ProteinPainRatsRats, Sprague-DawleySignal TransductionSirtuin 1InflammasomesInterleukin-18NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratSirt1 protein, ratSirtuin 1

Identifiers

PMID36059399
PMCPMC9439914
OpenAlexW4294607947

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.