Evidence map›Paper›PMID 36061560›Full record

ArticleFrontiers in cardiovascular medicine2022

Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury.

Podsawee Mongkolpathumrat, Nitirut Nernpermpisooth, Anusak Kijtawornrat, Faprathan Pikwong, Wannapat Chouyratchakarn, Rungrueang Yodsheewan, Sasimanas Unajak, Sarawut Kumphune

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Podsawee MongkolpathumratBiomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand.
Nitirut NernpermpisoothIntegrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
Anusak KijtawornratDepartment of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Faprathan PikwongBiomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand.
Wannapat ChouyratchakarnBiomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand.
Rungrueang YodsheewanDepartment of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Sasimanas UnajakDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Sarawut KumphuneBiomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protease enzymes contribute to the initiation of cardiac remodeling and heart failure after myocardial ischemic/reperfusion (I/R) injury. Protease inhibitors attenuate protease activity and limit left ventricular dysfunction and remodeling. Previous studies showed the cardioprotective effect of secretory leukocyte protease inhibitor (SLPI) against I/R injury. However, overexpression of SLPI gene in cardiovascular diseases has only been investigated in an

Indexed as

cardiac selective expressioncardioprotectiongene therapyischemic/reperfusion injurysecretory leukocyte protease inhibitor (SLPI)

Identifiers

PMID36061560
PMCPMC9437585

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.