Evidence map›Paper›PMID 36063138›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.

Patrick Haider, Julia B Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B Fischer, Walter S Speidl and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Patrick HaiderDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-6874-5349
Julia B Kral-PointnerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Manuel SalzmannDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Florian MoikDivision of Haematology and Haemostaseology, Comprehensive Cancer Center, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Sonja BleichertDivision of Vascular Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Waltraud C SchrottmaierInstitute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.
Christoph KaunDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Mira BrekaloDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Michael B FischerDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Walter S SpeidlDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Christian HengstenbergDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Bruno K PodesserLudwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.
Kurt Huber3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria.
Ingrid PabingerDivision of Haematology and Haemostaseology, Comprehensive Cancer Center, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Sylvia KnappLaboratory of Infection Biology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Frank BrombacherInstitute of Infectious Disease and Molecular Medicine, International Center for Genetic and Biotechnology Cape Town Component & University of Cape Town, Cape Town, South Africa.
Christine BrostjanDivision of Vascular Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Cihan AyDivision of Haematology and Haemostaseology, Comprehensive Cancer Center, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Johann WojtaDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-1282-9276
Philipp J HohensinnerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATLudwig Boltzmann Institute for Cancer Research · ATComprehensive Cancer Center Vienna · ATVienna General Hospital · ATSigmund Freud Privatuniversität Wien · ATThrombosis Research Institute · GBUniversität für Weiterbildung Krems · ATUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-4 (IL-4) and its receptors (IL-4R) promote the proliferation and polarization of macrophages. However, it is unknown if IL-4R also influences monocyte homeostasis and if steady state IL-4 levels are sufficient to affect monocytes. Employing full IL-4 receptor alpha knockout mice (IL-4Rα

Indexed as

MonocytesSignal TransductionAnimalsHomeostasisHumansInterleukin-4Interleukin-4 Receptor alpha SubunitMacrophagesMiceMice, Inbred BALB CMice, KnockoutReceptors, Cell SurfaceIl4 protein, mouseIl4ra protein, mouseInterleukin-4Interleukin-4 Receptor alpha SubunitReceptors, Cell Surfacehomeostasisimmunityinnateinterleukin-4monocytesreceptorssignal transduction

Identifiers

PMID36063138
PMCPMC9544925
OpenAlexW4294668994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.