Evidence map›Paper›PMID 36064322›Full record

ReviewCellular & molecular biology letters2022

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid.

Mohsen Karami Fath, Jalil Azami, Niloofar Jaafari, Mahsa Akbari Oryani, Nafiseh Jafari, Alireza Karim Poor, Ali Azargoonjahromi, Mohsen Nabi-Afjadi, Zahra Payandeh, Hamidreza Zalpoor and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular & molecular biology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Mohsen Karami FathDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Jalil AzamiFaculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Niloofar JaafariDepartment of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mahsa Akbari OryaniDepartment of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nafiseh JafariDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
Alireza Karim PoorSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ali AzargoonjahromiShiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-8243-1530
Mohsen Nabi-AfjadiDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Zahra PayandehDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden. Zpayandeh58@yahoo.com.ORCID http://orcid.org/0000-0003-2565-8231
Hamidreza ZalpoorShiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. hamidreza.zlpr1998@gmail.com.ORCID http://orcid.org/0000-0002-8057-2804
Dariush ShanehbandiDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden. dariush_shanehbandi@yahoo.com.ORCID http://orcid.org/0000-0002-9449-0607
Shiraz University of Medical Sciences · IRTabriz University of Medical Sciences · IRIran University of Medical Sciences · IRIslamic Azad University Medical Branch of Tehran · IRKharazmi University · IRMashhad University of Medical Sciences · IRTarbiat Modares University · IRTehran University of Medical Sciences · IRUrmia University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into the extracellular periphery by a variety of cells such as neoplastic cells. Given that exosomes have unique properties, they can be used as vectors and carriers of biological and medicinal particles like drugs for delivering to the desired areas. The proteins and RNAs being encompassed by the circulating exosomes in B-cell malignancies are deemed as the promising sources for diagnostic and prognostic biomarkers, as well as therapeutic agents. Exosomes can also provide a "snapshot" view of the tumor and metastatic landscape at any particular time. Further, clinical research has shown that exosomes are produced by immune cells such as dendritic cells can stimulate the immune system, so these exosomes can be used in antitumor vaccines. Despite the great potential of exosomes in the fields of diagnostic and treatment, further studies are in need for these purposes to reach a convergence notion. This review highlights the applications of exosomes in multiple immune-related diseases, including chronic lymphocytic leukemia, multiple sclerosis, and arthritis rheumatoid, as well as explaining sundry aspects of exosome therapy and the function of exosomes in diagnosing diseases.

Indexed as

ArthritisExosomesExtracellular VesiclesLeukemiaMultiple SclerosisNeoplasmsHumansProteinsProteinsAcute myeloid leukemiaCancerChronic lymphocytic leukemiaExosomeMultiple sclerosisRheumatic arthritis

Identifiers

PMID36064322
PMCPMC9446857
OpenAlexW4294653663

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.