ArticleNature communications2022
A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- The phenology of the European flat oyster (Ostrea edulis) and its environmental drivers.Scientific reports · 2026Article
- Evolutionary and physiological arguments for the existence of a circalunar clock in humans.BMC ecology and evolution · 2026Review
- Photoreceptor control ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity.Nature communications · 2025Article
- Structural Plasticity and Functional Dynamics of Pigeon Cryptochrome 4 as Avian Magnetoreceptor.Journal of molecular biology · 2025Article
- How Light at Night Sets the Circalunar Clock in the Marine MidgeJournal of biological rhythms · 2025Article
- Evaluating the role of moonlight-darkness dynamics as proximate spawning cues in anCoral reefs (Online) · 2025Article
- Time me by the moon : The evolution and function of lunar timing systems.EMBO reports · 2024Article
- Elongation capacity of polyunsaturated fatty acids in the annelidOpen biology · 2024Article
- Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior.PLoS biology · 2024Article
- A structural decryption of cryptochromes.Frontiers in chemistry · 2024Review
- All Light, Everywhere? Photoreceptors at Nonconventional Sites.Physiology (Bethesda, Md.) · 2024Review
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- A marine cryptochrome with an inverse photo-oligomerization mechanism.Nature communications · 2023Article
- A Fast And Versatile Method for Simultaneous HCR, Immunohistochemistry And Edu Labeling (SHInE).Integrative and comparative biology · 2023Article
- Dimerization of European Robin Cryptochrome 4a.The journal of physical chemistry. B · 2023Article
- Article
- Two light sensors decode moonlight versus sunlight to adjust a plastic circadian/circalunidian clock to moon phase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
The moon's monthly cycle synchronizes reproduction in countless marine organisms. The mass-spawning bristle worm Platynereis dumerilii uses an endogenous monthly oscillator set by full moon to phase reproduction to specific days. But how do organisms recognize specific moon phases? We uncover that the light receptor L-Cryptochrome (L-Cry) discriminates between different moonlight durations, as well as between sun- and moonlight. A biochemical characterization of purified L-Cry protein, exposed to naturalistic sun- or moonlight, reveals the formation of distinct sun- and moonlight states characterized by different photoreduction- and recovery kinetics of L-Cry's co-factor Flavin Adenine Dinucleotide. In Platynereis, L-Cry's sun- versus moonlight states correlate with distinct subcellular localizations, indicating different signaling. In contrast, r-Opsin1, the most abundant ocular opsin, is not required for monthly oscillator entrainment. Our work reveals a photo-ecological concept for natural light interpretation involving a "valence interpreter" that provides entraining photoreceptor(s) with light source and moon phase information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.