Evidence map›Paper›PMID 36065607›Full record

ArticleBlood cancer discovery2022

Reduced PU.1 Expression Collaborates with Tet2 Loss to Trigger Myeloid Leukemogenesis.

Wolfgang E Schleicher, Eric M Pietras

Open access · bronzeAbstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wolfgang E SchleicherDivision of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-6054-3435
Eric M PietrasDivision of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-7339-8828
University of Colorado Anschutz Medical Campus · US

Funding

Impact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0M
Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
Crosstalk between aberrant glycolysis and inflammation in clonal hematopoiesis.R56DK131461 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK119394NIDDK NIH HHS R56 DK131461NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

The leukemic transformation of hematopoietic stem and progenitor cells in the setting of Tet2 deficiency is driven by PU.1 gene network loss through complementary reduction in PU.1 expression and hypermethylation of ETS loci at the enhancers of PU.1 target genes. See related article by Aivalioti et al., p. 444 (6).

Indexed as

DioxygenasesLeukemia, MyeloidCell Transformation, NeoplasticDNA-Binding ProteinsHematopoiesisHumansProto-Oncogene ProteinsRegulatory Sequences, Nucleic AcidTrans-ActivatorsDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsTET2 protein, humanTrans-Activators

Identifiers

PMID36065607
PMCPMC9445751
OpenAlexW4294710586

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.