Evidence map›Paper›PMID 36066100›Full record

ArticlemBio2022

Vaccination with Live or Heat-Killed Aspergillus fumigatus Δ

Caroline Mota Fernandes, Tyler G Normile, Joao Henrique Tadini Marilhano Fabri, Veronica Soares Brauer, Glauber R de S Araújo, Susana Frases, Leonardo Nimrichter, Iran Malavazi, Maurizio Del Poeta

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026
    Article
  4. Molecular mechanisms drivingFrontiers in molecular biosciences · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Global, Regional, and National Burden of Pulmonary Fungal Infections 1990-2021.American journal of respiratory and critical care medicine · 2025
    Article
  10. Article
  11. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Sterylglucosides in Fungi.Journal of fungi (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Caroline Mota Fernandes *Department of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Tyler G Normile *Department of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Joao Henrique Tadini Marilhano FabriDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil.
Veronica Soares BrauerDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Glauber R de S AraújoInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Susana FrasesInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Leonardo NimrichterInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-9281-6856
Iran MalavaziDepartamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil.ORCID 0000-0002-4526-4961
Maurizio Del PoetaDepartment of Microbiology and Immunology, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0001-8418-3120
Stony Brook University · USUniversidade Federal do Rio de Janeiro · BRUniversidade Federal de São Carlos · BRNorthport VA Medical Center · US

Funding

New antifungals targeting the synthesis of fungal sphingolipidsR01AI116420 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Maurizio Del Poeta · 2016 to 2026
$7.6M
Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
Sphingosine-1-phosphate and cryptococcosisR01AI136934 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2018 to 2022
$2.5M
Role of host spingolipids against fungal infectionsI01BX002624 · VA · NORTHPORT VA MEDICAL CENTER · PI Maurizio Del Poeta · 2016 to 2026
–
BLRD Research Career Scientist Award ApplicationIK6BX005386 · VA · NORTHPORT VA MEDICAL CENTER · PI DEL POETA, MAURIZIO · 2021 to 2025
–
BLRD VA I01 BX002624BLRD VA IK6 BX005386NIAID NIH HHS R01 AI116420NIAID NIH HHS R01 AI125770NIAID NIH HHS R01 AI136934
6 · The paper itself

Abstract

Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients, resulting in high mortality rates. Currently, no vaccine formulations to promote immune protection in at-risk individuals have been developed. In this work, we deleted the sterylglucosidase-encoding gene,

Indexed as

AspergillosisInvasive Fungal InfectionsAnimalsAspergillus fumigatusCyclophosphamideGlycolipidsHot TemperatureImmunocompromised HostMiceSpores, FungalVaccinationCyclophosphamideGlycolipidsAspergillusAspergillus fumigatusconidiafungal infectionimmunizationimmunocompromised hostinvasive aspergillosissterylglucosidesvaccine

Identifiers

PMID36066100
PMCPMC9600187
OpenAlexW4294762681

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.