Evidence map›Paper›PMID 36066493›Full record

ArticleThe Journal of experimental medicine2022

Innatus immunis: Evolving paradigm of adaptive NK cells.

Mohamed Khalil, Subramaniam Malarkannan

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mohamed KhalilDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-6841-9620
Subramaniam MalarkannanDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-7511-2731
Medical College of Wisconsin · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
J. NRSA Training CoreTL1TR001437 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI THOMAS, DANNY GEORGE · 2015 to 2024
$3.7M
Molecular signature of inflammationR01CA179363 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI MALARKANNAN, SUBRAMANIAM · 2014 to 2018
$1.6M
Molecular mechanisms of signaling co-ordination in innate lymphocytesR01AI102893 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MALARKANNAN, SUBRAMANIAM · 2013 to 2016
$1.5M
NCATS NIH HHS TL1 TR001437NCATS NIH HHS UL1 TR001436NCI NIH HHS R01 CA179363NIAID NIH HHS R01 AI102893
6 · The paper itself

Abstract

The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220551) report that the development of FcRγ-/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings provide exciting new molecular blueprints explaining the development and functions of adaptive-like NK cells.

Indexed as

Killer Cells, NaturalTransforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID36066493
PMCPMC9449531
OpenAlexW4294756136

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.