Evidence map›Paper›PMID 36067030›Full record

SynthesisBrain and behavior2022

Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta-analysis.

Min Yang, Hang Cheng, Xia Wang, Menglu Ouyang, Sultana Shajahan, Cheryl Carcel, Craig Anderson, Espen Saxhaug Kristoffersen, Yapeng Lin, Else Charlotte Sandset and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  8. Review
  9. Persistence and Adherence to Cardiovascular Medicines in Australia.Journal of the American Heart Association · 2023
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Min YangDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Hang ChengDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Xia WangThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
Menglu OuyangThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
Sultana ShajahanThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
Cheryl CarcelThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
Craig AndersonThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
Espen Saxhaug KristoffersenDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Yapeng LinDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Else Charlotte SandsetStroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.
Xiaoyun WangDepartment of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Jie YangDepartment of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
UNSW Sydney · AUFirst Affiliated Hospital of Chengdu Medical College · CNOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NOThe University of Sydney · AUUniversity of Electronic Science and Technology of China · CNThe George Institute for Global Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to investigate the prescription of antithrombotic drugs (including anticoagulants and antiplatelets) and medication adherence after stroke.

methodsWe performed a systematic literature search across MEDLINE and Embase, from January 1, 2015, to February 17, 2022, to identify studies reporting antithrombotic medications (anticoagulants and antiplatelets) post stroke. Two people independently identified reports to include, extracted data, and assessed the quality of included studies according to the Newcastle-Ottawa scale. Where possible, data were pooled using random-effects meta-analysis.

resultsWe included 453,625 stroke patients from 46 studies. The pooled proportion of prescribed antiplatelets and anticoagulants among patients with atrial fibrillation (AF) was 62% (95% CI: 57%-68%), and 68% (95% CI: 58%-79%), respectively. The pooled proportion of patients who were treated according to the recommendation of guidelines of antithrombotic medications from four studies was 67% (95% CI: 41%-93%). It was reported that 11% (95% CI: 2%-19%) of patients did not receive antithrombotic medications. Good adherence to antiplatelet, anticoagulant, and antithrombotic medications was 78% (95% CI: 67%-89%), 71% (95% CI: 57%-84%), and 73% (95% CI: 59%-86%), respectively.

conclusionIn conclusion, we found that less than 70% of patients were prescribed and treated according to the recommended guidelines of antithrombotic medications, and good adherence to antithrombotic medications is only 73%. Prescription rate and good adherence to antithrombotic medications still need to be improved among stroke survivors.

Indexed as

Fibrinolytic AgentsStrokeAnticoagulantsHumansPlatelet Aggregation InhibitorsPrescriptionsSurvivorsAnticoagulantsFibrinolytic AgentsPlatelet Aggregation Inhibitorsanticoagulantantiplateletantithromboticsecondary preventionstrokesystematic review

Identifiers

PMID36067030
PMCPMC9575604
OpenAlexW4294804935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.