Evidence map›Paper›PMID 36067064›Full record

ArticleThe journal of physical chemistry. B2022

Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation.

Robert Allsopp, Anna Pavlova, Tyler Cline, Aria M Salyapongse, Richard E Gillilan, Y Peter Di, Berthony Deslouches, Jeffery B Klauda, James C Gumbart, Stephanie Tristram-Nagle

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

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  9. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Robert AllsoppDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
Anna PavlovaSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Tyler ClineDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
Aria M SalyapongseBiological Physics Group, Physics Department, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Richard E GillilanCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, New York 14853, United States.
Y Peter DiDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0003-2028-2087
Berthony DeslouchesDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
Jeffery B KlaudaDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0001-8725-1870
James C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-1510-7842
Stephanie Tristram-NagleBiological Physics Group, Physics Department, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0003-2271-7056
University of Maryland, College Park · USCarnegie Mellon University · USGeorgia Institute of Technology · USUniversity of Pittsburgh · USCornell University · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Novel antimicrobial agents to overcome antibiotic resistant Pseudomonas and MRSA respiratory infectionR01AI133351 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DI, YUANPU PETER · 2017 to 2021
$2.6M
Determinants and Mechanisms of Efficacy of Peptide Antibiotics as Novel Sepsis TherapyR01GM125917 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DESLOUCHES, BERTHONY · 2018 to 2022
$2.1M
Dynamic characterization of outer-membrane-protein biogenesis by the BAM and TAM complexesR01GM123169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133351NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R01 GM123169NIGMS NIH HHS R01 GM125917
6 · The paper itself

Abstract

In an effort to combat rising antimicrobial resistance, our labs have rationally designed cationic, helical, amphipathic antimicrobial peptides (AMPs) as alternatives to traditional antibiotics since AMPs incur bacterial resistance in weeks, rather than days. One highly positively charged AMP, WLBU2 (+13

Indexed as

Antimicrobial PeptidesMolecular Dynamics SimulationAntimicrobial Cationic PeptidesBacteriaLipid BilayersLipidsPhosphatesWaterAntimicrobial Cationic PeptidesAntimicrobial PeptidesLipid BilayersLipidsPhosphatesWater

Identifiers

PMID36067064
PMCPMC10392866
OpenAlexW4294796304

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.