Evidence map›Paper›PMID 36067277›Full record

ArticleCirculation2022

Gain-of-Function Variants in Lipid Genes Enhance Biological Insight and Point Toward Therapeutic Opportunities.

Sylvia Stankov, Cecilia Vitali, Daniel J Rader

Abstract readEditorialComment
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sylvia StankovDivision of Translational Medicine and Therapeutics, Department of Medicine (S.S., C.V., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.ORCID 0000-0002-6775-7564
Cecilia VitaliDivision of Translational Medicine and Therapeutics, Department of Medicine (S.S., C.V., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.ORCID 0000-0002-4519-0798
Daniel J RaderDivision of Translational Medicine and Therapeutics, Department of Medicine (S.S., C.V., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.ORCID 0000-0002-9245-9876

Funding

Structure-Function Analysis of Triglyceride Regulators ApoC-III and ApoA-V Using Natural VariantsR01HL133502 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2016 to 2023
$3.9M
NHLBI NIH HHS R01 HL133502
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DyslipidemiasGain of Function MutationCholesterol, HDLCholesterol, LDLHumansTriglyceridesCholesterol, HDLCholesterol, LDLTriglyceridescholesterol, HDLcholesterol, LDLdyslipidemiasEditorialsgain-of-function mutationLIPC protein, humanphospholipases

Identifiers

PMID36067277
PMCPMC10122829

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.