ArticleClinical research in cardiology : official journal of the German Cardiac Society2023
Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Overview of hypertension in Saudi Arabia: A systematic review and meta-analysis.Saudi medical journal · 2023Pooled it
- Effects of smoking cessation interventions on vascular health markers: a scoping review.Internal and emergency medicine · 2026Article
- Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders.Aging cell · 2026Article
- Breathing bad: increased risk for obstructive sleep apnea in current and former smokers.Scientific reports · 2026Article
- Undiagnosed and Uncontrolled Hypertension in the Aseer Region, Saudi Arabia: A Ramadan Screening Study with Long-Term Trends (1990-2019) and Projections to 2027.International journal of general medicine · 2026Article
- Exploring the Impact of E-cigarettes on Cardiovascular Health: Insights from Preclinical and Clinical Studies.Cardiovascular toxicology · 2025Review
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Associations of cardiovascular health with arterial health in adults free of cardiovascular disease.American journal of preventive cardiology · 2025Article
- Maternal Vascular Adaptation in High-Risk Pregnancies: Effects of Early Smoking Cessation on Hemodynamic and Endothelial Function.International journal of molecular sciences · 2025Article
- What Increases Smokers' Stress? Degree of Nicotine Dependence and Motivation to Quit Smoking in People After Myocardial Infarction.Journal of clinical medicine · 2025Article
- Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study.European journal of preventive cardiology · 2025Article
- Analysis of risk factors for major adverse cardiac events in patients with multiple myeloma.Frontiers in cardiovascular medicine · 2025Article
- Tobacco smoking and biomarker profile among beverage industrial workers and their spouses in Rwanda: A cross-sectional study.PLOS global public health · 2025Article
- Small vessel disease burden and prognosis of recent subcortical ischaemic stroke differ by parent artery atherosclerosis.European journal of neurology · 2024Article
- The Impact of Smoking on Arterial Stiffness in Young Adults: A Prospective Analysis.Healthcare (Basel, Switzerland) · 2024Article
- Association between sleep regularity and arterial stiffness among middle-age adults in Southwestern China.BMC public health · 2024Article
- The Relationship between Healthy Vascular Aging with the Mediterranean Diet and Other Lifestyles in the Spanish Population: The EVA Study.Nutrients · 2024Article
- Smoking, Alcohol Consumption, and Risk of Arterial Stiffness: A Two-Sample Mendelian Randomization Study.Reviews in cardiovascular medicine · 2024Article
- Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI).Current hypertension reviews · 2024Article
- Impact of social isolation during COVID-19 on anthropometric data, quality of life, baseline physical activity and aortic pulse wave parameters in children and adolescents in two independent samples.Italian journal of pediatrics · 2023Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event in the development of atherosclerotic CVD, remain still elusive. Thus, this study sought out to investigate sex-specific associations between smoking and measures of arterial stiffness. METHODS AND
resultsOverall, 15,010 participants (7584 men and 7426 women aged 35-74 years) of the Gutenberg Health Study were examined at baseline during 2007-2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a standardized computer-assisted interview. Arterial stiffness and wave reflection were determined by stiffness index (SI) and augmentation index (AI). In the total sample, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Median cumulative smoking exposure was 22.0 pack-years in current male smokers and 16.0 in current female smokers. In general, multivariable linear regression models adjusted for a comprehensive set of confounders revealed that smoking status, pack-years of smoking, and years since quitting smoking were dose-dependently associated with markers of arterial stiffness. In sex-specific analyses, these associations were overall more pronounced in men and SI was stronger related to the male sex, whereas differences between men and women in the case of AI appeared to be less substantial. DISCUSSION: The present results indicate that chronic smoking is strongly and dose-dependently associated with increased arterial stiffness in a large population-based cohort regardless of sex but with a stronger association in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.