Evidence map›Paper›PMID 36068397›Full record

ReviewHuman cell2022

Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases.

Agieshkumar Balakrishna Pillai, Vignesh Mariappan, Aashika Raagavi JeanPierre, S R Rao

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Food science & nutrition · 2024
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Agieshkumar Balakrishna PillaiMGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India. agiesh.b@gmail.com.ORCID http://orcid.org/0000-0002-6543-2977
Vignesh MariappanMGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India.ORCID http://orcid.org/0000-0001-7405-3998
Aashika Raagavi JeanPierreMGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India.ORCID http://orcid.org/0000-0002-1556-3055
S R RaoResearch, Innovation and Development (R,I&D), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India.ORCID http://orcid.org/0000-0002-4267-974X
Sri Balaji Vidyapeeth University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction is one of the key cornerstone complications of emerging and re-emerging viruses which lead to vascular leakage and a high mortality rate. The mechanism that regulates the origin of endothelial dysregulation is not completely elucidated. Currently, there are no potential pharmacological treatments and curable management for such diseases. In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. Thus, we have discussed the therapeutic role of MSCs in restoring vascular integrity by (i) inhibiting the metalloprotease activity thereby preventing the cleavage of tight junction proteins, which are essential for maintaining membrane integrity (ii) possessing antioxidant properties which neutralize the excessive ROS production due to virus infection and its associated hyper host immune response (iii) modulating micro RNAs that regulate the endothelial activation and its integrity by downregulating the inflammatory response during ssRNA infection.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationVirus DiseasesAntioxidantsEndothelial CellsHumansMetalloproteasesReactive Oxygen SpeciesRNATight Junction ProteinsAntioxidantsMetalloproteasesReactive Oxygen SpeciesRNATight Junction ProteinsCOVID-19CytotherapyEndothelial damageStem cellViral haemorrhagic fever

Identifiers

PMID36068397
PMCPMC9447969
OpenAlexW4294818969

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.