Evidence map›Paper›PMID 36068552›Full record

ArticleClinical epigenetics2022

Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population.

Krzysztof Laudanski, Da Liu, Jihane Hajj, Danyal Ghani, Wilson Y Szeto

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Krzysztof LaudanskiDepartment of Anesthesiology and Critical Care, University of Pennsylvania, JMB 127, 3620 Hamilton Walk, Philadelphia, PA, 19146, USA. klaudanski@gmail.com.
Da LiuDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Jihane HajjSchool of Nursing, Widener University, Philadelphia, PA, USA.
Danyal GhaniDepartment of Cardiac Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Wilson Y SzetoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USChina Medical University · CNWidener University · US

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Epigenetic mediated long-term aberrations in myeloid cells after critical illnessK23GM120630 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LAUDANSKI, KRZYSZTOF · 2017 to 2020
$783k
NIA NIH HHS P30 AG010124NIGMS NIH HHS K23 GM120630
6 · The paper itself

Abstract

backgroundDespite clinical relevance of immunological activation due to histone leakage into the serum following cardiac surgery, long-term data describing their longitudinal dynamic are lacking. Therefore, this study examines the serum levels of histone 3 (tH3) and its modifications (H3K4me3 and H3K27ac) alongside immune system activation during the acute and convalescence phases of cardiac surgery.

methodsBlood samples from fifty-nine individuals were collected before non-emergent cardiac surgery (t

resultsCompared to pre-operative levels (tH3

conclusionsWe demonstrated a prolonged elevation in serum histone 3 three months after cardiac surgery. Furthermore, histone 3 modifications had a discrete time evolution indicating differential immune activation.

Indexed as

Cardiac Surgical ProceduresHistonesAdultC-Reactive ProteinDNA MethylationHumansInflammationInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaC-Reactive Proteinhistone H3 trimethyl Lys4HistonesInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaAcetaminophenCardiac surgeryH3K427acH3K4me3Histone 3Long-term outcomeSmoldering inflammation

Identifiers

PMID36068552
PMCPMC9446722
OpenAlexW4294733784

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.