Evidence mapPaperPMID 36069443Full record

ArticlemBio2022

Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria.

Maithri L Sarangam, Ruth Namazzi, Dibyadyuti Datta, Caitlin Bond, Charles P B Vanderpool, Robert O Opoka, Chandy C John, Andrea L Conroy

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The gut microbiome in early life predicts malaria susceptibility.Frontiers in cellular and infection microbiology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
  13. Enhanced Mouse Susceptibility to Endotoxin Shock afterInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Maithri L SarangamUniversity of Washington, Seattle, Washington, USA.
Ruth NamazziDepartment of Paediatrics and Child Health, Makerere Universitygrid.11194.3c College of Health Sciences, Kampala, Uganda.
Dibyadyuti DattaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Caitlin BondDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Charles P B VanderpoolDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Robert O OpokaDepartment of Paediatrics and Child Health, Makerere Universitygrid.11194.3c College of Health Sciences, Kampala, Uganda.
Chandy C JohnDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrea L ConroyDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5328-6511
Indiana University School of MedicineCenter for Global Health · USWorld Health Organization - Uganda · UGUniversity of Washington · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · 2022 to 2025
$2.9M
Northern Pacific Global Health Leadership, Education, and Development for Early-career Researchers (NPGH LEADERs)D43TW009345 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$1.6M
Research training in infection and neurodevelopment in UgandaD43TW010928 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$284k
FIC NIH HHS D43 TW009345FIC NIH HHS D43 TW010928FIC NIH HHS R25 TW009345NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

Severe malaria (SM) increases the risk of invasive bacterial infection, and there is evidence to suggest increased gastrointestinal permeability. Studies have shown sequestration of infected erythrocytes in intestinal microvasculature, and

Indexed as

Acute Kidney InjuryMalariaAngiopoietin-2BiomarkersChildFatty Acid-Binding ProteinsHumansPatient DischargeTrefoil Factor-3Angiopoietin-2BiomarkersFatty Acid-Binding ProteinsTrefoil Factor-3acidosisacute kidney injuryglobal healthI-FABPintestinal injurymortalitypediatricssevere malariaTFF3

Identifiers

PMID36069443
PMCPMC9601216
OpenAlexW4294921172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.