Evidence map›Paper›PMID 36069447›Full record

ArticlemBio2022

The Group B Streptococcal Adhesin BspC Interacts with Host Cytokeratin 19 To Promote Colonization of the Female Reproductive Tract.

Haider S Manzer, Dustin T Nguyen, Joo Youn Park, Nogi Park, Keun Seok Seo, Justin A Thornton, Angela H Nobbs, Kelly S Doran

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Identification of glyoxalase A in group BInfection and immunity · 2025
    Article
  3. Mechanisms and Manifestations of Group B Streptococcus Meningitis in Newborns.Journal of the Pediatric Infectious Diseases Society · 2025
    Review
  4. Identification of Glyoxalase A in Group BbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Haider S ManzerUniversity of Colorado Anschutz Medical Campus, Department of Immunology and Microbiology, Aurora, Colorado, USA.ORCID 0000-0002-2864-6212
Dustin T NguyenUniversity of Colorado Anschutz Medical Campus, Department of Immunology and Microbiology, Aurora, Colorado, USA.
Joo Youn ParkMississippi State Universitygrid.260120.7, Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State, Mississippi, USA.ORCID 0000-0002-8375-0178
Nogi ParkMississippi State Universitygrid.260120.7, Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State, Mississippi, USA.
Keun Seok SeoMississippi State Universitygrid.260120.7, Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State, Mississippi, USA.ORCID 0000-0001-9280-9680
Justin A ThorntonMississippi State Universitygrid.260120.7, Department of Biological Sciences, Mississippi State, Mississippi, USA.
Angela H NobbsUniversity of Bristolgrid.5337.2, Bristol Dental School, Bristol, United Kingdom.ORCID 0000-0003-3813-4410
Kelly S DoranUniversity of Colorado Anschutz Medical Campus, Department of Immunology and Microbiology, Aurora, Colorado, USA.ORCID 0000-0003-4232-6837
Mississippi State University · USUniversity of Colorado Anschutz Medical Campus · USUniversity Of Bristol Dental Hospital · GB

Funding

Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI NANDURI, BINDU · 2013 to 2022
$21.1M
Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tractR01AI153332 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2021 to 2025
$2.9M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Modulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial MeningitisR01NS116716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2020 to 2024
$1.9M
Characterizing the Contribution of the Group B Streptococcal Surface Adhesin BspC Interaction with Host Vimentin to Disease and ColonizationF31AI164674 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MANZER, HAIDER SYED · 2021 to 2022
$69k
NIAID NIH HHS F31 AI164674NIAID NIH HHS R01 AI153332NIAID NIH HHS T32 AI052066NIGMS NIH HHS P20 GM103646NINDS NIH HHS R01 NS116716
6 · The paper itself

Abstract

Streptococcus agalactiae, otherwise known as Group B Streptococcus (GBS), is an opportunistic pathogen that vaginally colonizes approximately one third of healthy women. During pregnancy, this can lead to

Indexed as

ChorioamnionitisPremature BirthSepsisStreptococcal InfectionsAdhesins, BacterialAnimalsBacterial ProteinsChemokinesFemaleHumansKeratin-19MicePregnancyStreptococcus agalactiaeVaginaAdhesins, BacterialBacterial ProteinsChemokinesKeratin-19antigen I/IIanti-virulencecytokeratin-19group B streptococcustherapeuticsvaginal colonization

Identifiers

PMID36069447
PMCPMC9600255
OpenAlexW4294920762

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.