SynthesisEuropean heart journal. Cardiovascular Imaging2022
Pericoronary fat attenuation index-a new imaging biomarker and its diagnostic and prognostic utility: a systematic review and meta-analysis.
Synthesis in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Correlation Between Fat Attenuation Index and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin.Circulation. Cardiovascular imaging · 2025Trial
- Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023 · on this mapTrial
- Correlation between the coronary computed tomography angiography-derived pericoronary fat attenuation index and coronary artery lesions in Kawasaki disease.Quantitative imaging in medicine and surgery · 2026Article
- Role of artificial intelligence in developing predictive models for major adverse cardiovascular outcomes using CCTA adipose tissue characteristics: a systematic review and meta-analysis.European heart journal. Digital health · 2026Review
- Convalescent Spontaneous Coronary Artery Dissection With Elevated Pericoronary Fat Attenuation Index.JACC. Case reports · 2026Article
- Review
- Advanced Multimodality Cardiovascular Imaging in Patients at Very High Cardiovascular Risk Without a Previous Cardiovascular Event: Current Knowledge and Future Perspectives.Journal of cardiovascular development and disease · 2026Review
- Association of Relative Pericoronary Adipose Tissue Attenuation with Coronary Artery Calcification Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Exploration of the Effects of SGLT-2 Inhibitors and GLP-1 Receptor Agonists on Coronary Inflammation in Type 2 Diabetes Patients Based on the Peri-Coronary Fat Attenuation Index.Reviews in cardiovascular medicine · 2026Article
- Cardiac computed tomography unmasks cardiac involvement in immune complex vasculitis in a patient with chest pain and shortness of breath.European heart journal. Case reports · 2026Article
- Epicardial Adipose Tissue CT Radiomics Improves Acute Coronary Syndrome Prediction Beyond Coronary Artery Calcium Score.Diagnostics (Basel, Switzerland) · 2026Article
- Pericoronary Adipose Tissue Radiomic Features and Quantitative Plaque Analysis in Coronary Artery Disease: Insights from Coronary Computed Tomography Angiography.Diagnostics (Basel, Switzerland) · 2026Article
- Pericoronary Fat Attenuation Index and MRI-Derived Coronary Flow Reserve: A Comparative Study in Suspected Versus Known Coronary Artery Disease.Tomography (Ann Arbor, Mich.) · 2026Article
- Coronary Plaque Vulnerability and Pericoronary Adipose Tissue Inflammation: Emerging Insights from Advanced CT Imaging.Medicina (Kaunas, Lithuania) · 2026Review
- Feasibility of Artificial Intelligence Models for Longitudinal CT Analysis of Epicardial Adipose Tissue After Immunotherapy.Diagnostics (Basel, Switzerland) · 2026Article
- Effect of perivascular adipose tissue on patency and maturation rate of arteriovenous fistula in hemodialysis patients.International urology and nephrology · 2026Article
- Combined lesion-specific pericoronary adipose tissue attenuation and triglyceride-glucose body mass index for improved risk stratification of major adverse cardiovascular events in patients with stable angina pectoris.Quantitative imaging in medicine and surgery · 2026Article
- Pericoronary fat attenuation index predicts vulnerable plaque and adverse outcomes in coronary heart disease.Journal of thoracic disease · 2026Article
- Relationship Between Perivascular Fat Inflammation and Coronary Atherosclerotic Plaque Composition.Journal of clinical medicine · 2026Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pericoronary fat attenuation index (FAI) on coronary computed tomography angiography imaging has been proposed as a novel marker of coronary vascular inflammation with prognostic value for major cardiovascular events. To date, there is no systematic review of the published literature and no meta-analysed data of previously published results. We performed a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. We systematically explored published literature in MEDLINE (PubMed) before 20 January 2022 for studies assessing FAI in both diagnostic and prognostic clinical settings in patients with or without cardiovascular disease. The primary outcome was the mean difference in FAI attenuation between stable and unstable coronary plaques. The secondary outcome was the hazard ratio (HR) of high FAI values for future cardiovascular events. We calculated I2 to test heterogeneity. We used random-effects modelling for the meta-analyses to assess the primary and secondary outcomes. This study is registered with PROSPERO (CRD42021229491). In total, 20 studies referred in a total of 7797 patients were included in this systematic review, while nine studies were used for the meta-analysis. FAI was significantly higher in unstable compared with stable plaques with a mean difference of 4.50 Hounsfield units [95% confidence interval (CI): 1.10-7.89, I2 = 88%] among 902 patients. Higher pericoronary FAI values offered incremental prognostic value for major adverse cardiovascular events (MACEs) in studies with prospective follow-up (HR = 3.29, 95% CI: 1.88-5.76, I2 = 75%) among 6335 patients. Pericoronary FAI seems to be a promising imaging biomarker that can be used for the detection of coronary inflammation, possibly to discriminate between stable and unstable plaques, and inform on the prognosis for future MACE. Further validation of these findings and exploration of the cost-effectiveness of the method before implementation in clinical practice are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.